Activating transcription factor 3 and the nervous system.
Activating transcription factor 3 and the nervous system.
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DOI：
10.3389/fnmol.2012.00007
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发表时间：
2012
影响因子：
4.8
通讯作者：
Anderson PN
中科院分区：
文献类型：
--
作者：
Hunt D;Raivich G;Anderson PN
转录激活因子3（Activating transcription factor 3，ATF 3）属于转录因子ATF/环腺苷酸应答元件结合家族，是一种适应性反应基因，其活性受应激刺激的调节。尽管以许多剪接变体表达并且通常被认为是转录抑制因子，但ATF 3具有与许多其他转录因子（包括c-Jun）相互作用以形成复合物的能力，所述复合物不仅抑制，而且还可以激活各种基因。ATF 3的表达主要在转录水平上调节，并且在不同类型的细胞中具有显著不同的作用。在神经元和神经胶质细胞中，ATF 3 mRNA和蛋白的水平通常非常低，但它们的表达响应于损伤而迅速上调。神经元中的ATF 3表达与轴突切断后它们的存活和轴突再生密切相关，并且在外周神经中的表达与有助于轴突再生的雪旺细胞表型的产生相关。ATF 3也由Toll样受体（TLR）配体诱导，但作为TLR信号传导的负调节剂，抑制参与免疫监视的先天免疫应答，并且可以增强或减少受损神经元的存活并促进其轴突的再生。
Activating transcription factor 3 (ATF3) belongs to the ATF/cyclic AMP responsive element binding family of transcription factors and is often described as an adaptive response gene whose activity is usually regulated by stressful stimuli. Although expressed in a number of splice variants and generally recognized as a transcriptional repressor, ATF3 has the ability to interact with a number of other transcription factors including c-Jun to form complexes which not only repress, but can also activate various genes. ATF3 expression is modulated mainly at the transcriptional level and has markedly different effects in different types of cell. The levels of ATF3 mRNA and protein are normally very low in neurons and glia but their expression is rapidly upregulated in response to injury. ATF3 expression in neurons is closely linked to their survival and the regeneration of their axons following axotomy, and that in peripheral nerves correlates with the generation of a Schwann cell phenotype that is conducive to axonal regeneration. ATF3 is also induced by Toll-like receptor (TLR) ligands but acts as a negative regulator of TLR signaling, suppressing the innate immune response which is involved in immuno-surveillance and can enhance or reduce the survival of injured neurons and promote the regeneration of their axons.
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影响因子：
3.7
作者：
Cook AL;Vitale AM;Ravishankar S;Matigian N;Sutherland GT;Shan J;Sutharsan R;Perry C;Silburn PA;Mellick GD;Whitelaw ML;Wells CA;Mackay-Sim A;Wood SA
通讯作者：
Wood SA
影响因子：
15.1
作者：
Bernstein AI;Garrison SP;Zambetti GP;O'Malley KL
通讯作者：
O'Malley KL
影响因子：
7.4
作者：
Christianson CA;Corr M;Firestein GS;Mobargha A;Yaksh TL;Svensson CI
通讯作者：
Svensson CI
影响因子：
7.4
作者：
Carlton SM;Du J;Tan HY;Nesic O;Hargett GL;Bopp AC;Yamani A;Lin Q;Willis WD;Hulsebosch CE
通讯作者：
Hulsebosch CE
影响因子：
3.4
作者：
Bradbury, EJ;Khemani, S;McMahon, SB
通讯作者：
McMahon, SB