A Case of Human Viral Encephalitis Caused by Pseudorabies Virus Infection in China
A Case of Human Viral Encephalitis Caused by Pseudorabies Virus Infection in China
复制标题
我国伪狂犬病病毒感染引起的人类病毒性脑炎一例
DOI：
10.3389/fneur.2019.00534
复制
发表时间：
2019-06-04
影响因子：
3.4
通讯作者：
Ding, ShiFang
中科院分区：
文献类型：
--
作者：
Yang, HongNa;Han, Hui;Ding, ShiFang
我们在中国报告一例由伪狂犬病毒（PRV）引起的病毒性脑炎。43岁男性，无既往病史，表现为高热、头痛、强直阵挛性发作以及昏迷。颅脑CT平扫显示双侧基底节区、双侧枕叶、双侧边缘叶、左丘脑低密度。下一代测序（NGS）证实了PRV在脑脊液（CSF）中的存在。应用常规聚合酶链反应（PCR）确认猪瘟病毒在脑脊液和血液中的存在。此外，使用血清学（免疫学）试验进一步验证外周血中是否存在PRV。提示PRV有可能导致人类中枢神经系统（CNS）感染，人们在接触动物时应提高自我保护意识。
We report a human case of viral encephalitis caused by pseudorabies virus (PRV) in China. A 43-year-old man with no previous medical history presented with high-grade fever, headache and tonic-clonic seizures as well as coma. Plain computer tomography (CT) brain imaging showed hypo-density in the bilateral basal ganglia, bilateral occipital lobe, bilateral limbic lobe, and left thalamic. Next-generation sequencing (NGS) confirmed the presence of PRV in cerebral spinal fluid (CSF). Regular polymerase chain reaction (PCR) was applied to confirm the presence of PRV in the CSF and blood. In addition, serological (immunological) tests were used to further validate the presence of PRV in the peripheral blood. This case suggested that it was possible for PRV to result in human central nervous system (CNS) infection, and it is necessary for people to increase awareness of self-protection when contacting animals.