Changes in putamen N-acetylaspartate and choline ratios in untreated and levodopa-treated Parkinson's disease: A proton magnetic resonance spectroscopy study
Changes in putamen N-acetylaspartate and choline ratios in untreated and levodopa-treated Parkinson's disease: A proton magnetic resonance spectroscopy study
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DOI：
10.1212/wnl.49.2.438
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发表时间：
1997-08-01
期刊：
影响因子：
9.9
通讯作者：
Chaudhuri, KR
中科院分区：
文献类型：
--
作者：
Ellis, CM;Lemmens, G;Chaudhuri, KR
We have carried out single-voxel proton magnetic resonance spectroscopy centered on the putamen both ipsilateral and contralateral to the worst affected side in nine subjects with drug naive idiopathic Parkinson's disease (IPD); seven chronically levodopa-treated dyskinetic IPD subjects; and 11 age-matched healthy controls. Measurements of N-acetylaspartate (NAA)/choline (Cho), NAA/(Creatine + Phosphocreatine) (Cr+PCr), and Cho/(Cr+PCr) were made. We found a significant reduction in NAA/Cho ratios from the putamen contralateral to the most affected side in the drug-naive group (p = 0.009), but not the levodopa-treated IPD groups compared with controls, There were no significant differences in NAA/(Cr+PCr) or Cho/(Cr+PCr) ratios. In untreated IPD, reduced putaminal NAA/Cho ratios may reflect loss of nigrostriatal dopamine terminals or alternatively indicate a functional abnormality of striatal putaminal neurons, such as membrane dysfunction due to striatal deafferentation. This study suggests that NAA/Cho ratios may be affected by L-dopa therapy and this may provide a reversible marker of neuronal dysfunction in the striatum.
