Trypanosoma vivax Adhesion to Red Blood Cells in Experimentally Infected Sheep.
Trypanosoma vivax Adhesion to Red Blood Cells in Experimentally Infected Sheep.
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DOI：
10.1155/2016/4503214
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发表时间：
2016-01-01
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影响因子：
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通讯作者：
Reyna-Bello, Armando
中科院分区：
文献类型：
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作者：
Boada-Sucre, Alpidio A;Rossi Spadafora, Marcello Salvatore;Reyna-Bello, Armando
锥虫病是一种全球性的寄生虫病，是热带和亚热带地区畜牧业生产的主要障碍，造成有形的经济损失。在包括委内瑞拉在内的拉丁美洲，反刍动物的锥虫病主要由间日锥虫引起。锥体产生的生物活性物质，以及宿主-锥体细胞相互作用，都有助于感染性贫血的发病。本研究的目的是用扫描电子显微镜观察实验感染间日疟原虫的绵羊红细胞(RBC)的细胞相互作用和变化。绵羊感染后，红细胞形态发生改变，并形成表面孔或小泡。一种常见的观察是锥虫的游离鞭毛、细胞体或附着的鞭毛在锥虫表面的丝足发射介导的过程中与绵羊红细胞的粘连。观察到的红细胞变化是由发生在血液中的宿主-寄生虫相互作用造成的机械和生化损害引起的。在感染期间，改变的红细胞容易被单核吞噬细胞清除，导致红细胞压积降低。
Trypanosomosis, a globally occurring parasitic disease, poses as a major obstacle to livestock production in tropical and subtropical regions resulting in tangible economic losses. In Latin America including Venezuela, trypanosomosis of ruminants is mainly caused by Trypanosoma vivax. Biologically active substances produced from trypanosomes, as well as host-trypanosome cellular interactions, contribute to the pathogenesis of anemia in an infection. The aim of this study was to examine with a scanning electron microscope the cellular interactions and alterations in ovine red blood cells (RBC) experimentally infected with T. vivax. Ovine infection resulted in changes of RBC shape as well as the formation of surface holes or vesicles. A frequent observation was the adhesion to the ovine RBC by the trypanosome's free flagellum, cell body, or attached flagellum in a process mediated by the filopodia emission from the trypanosome surface. The observed RBC alterations are caused by mechanical and biochemical damage from host-parasite interactions occurring in the bloodstream. The altered erythrocytes are prone to mononuclear phagocytic removal contributing to the hematocrit decrease during infection.