The role of Tenascin-C and Twist1 in gastric cancer: cancer progression and prognosis
The role of Tenascin-C and Twist1 in gastric cancer: cancer progression and prognosis
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Tenascin-C 和 Twist1 在胃癌中的作用：癌症进展和预后
DOI：
10.1111/apm.12919
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发表时间：
2019-02-01
期刊：
影响因子：
2.8
通讯作者：
Xuan, Yanhua
中科院分区：
文献类型：
--
作者：
Qi, Wenbo;Yang, Zhaoting;Xuan, Yanhua
本研究的目的是确定Tenascin-C（TNC）和Twist 1之间的关系，并确定其在胃癌（GC）中的临床意义。我们用免疫组织化学方法分析了159例胃癌和91例非肿瘤组织中TNC和Twist 1的表达。在本研究中，胃癌间质成纤维细胞的TNC表达明显高于非肿瘤性胃病变。胃癌间质成纤维细胞中TNC的表达与肿瘤的pT分期、淋巴结转移、远处转移密切相关。Twist 1在胃癌间质成纤维细胞中的表达显著高于非肿瘤性胃病变。Twist 1在胃癌间质成纤维细胞中的表达与肿瘤大小、淋巴结转移和临床分期有关。此外，GC基质成纤维细胞中的TNC表达水平与Twist 1呈正相关。TNC和Twist 1在胃癌间质成纤维细胞中的同时表达显著高于癌旁组织。TNC和Twist 1在胃癌间质成纤维细胞中的同时表达与肿瘤部位、pT分期、淋巴结转移和临床分期呈正相关。此外，TNC和Twist 1共表达的胃癌患者的预后比TNC或Twist 1阳性的患者更差。TNC和Twist 1同时表达提示胃癌预后较差。TNC和Twist 1的共靶点具有显著的临床优势，这为GC提供了一个新的治疗靶点。
The aim of the present study was to identify the relation between Tenascin-C (TNC) and Twist1 and determine their clinical significance in gastric cancer (GC). We analyzed the expression of TNC and Twist1 in 159 GC samples and in 91 non-tumor samples using immunohistochemistry. In this study, TNC expression in stromal fibroblasts of GC was remarkably higher than non-tumor gastric lesions. The expression of TNC in GC stromal fibroblasts was significantly associated with pT stage, lymph node metastasis, distant metastasis. Twist1 expression in stromal fibroblasts of GC was remarkably higher than non-tumor gastric lesions. Twist1 expression in the stromal fibroblasts of GC was associated with tumor size, lymph node metastasis, and clinical stage. Furthermore, TNC expression levels in GC stromal fibroblasts were positively associated with Twist1. The simultaneous expression of TNC and Twist1 was significantly higher in stromal fibroblasts of GC than in noncancerous tissues. The simultaneous expression of TNC and Twist1 in GC stromal fibroblasts was positively associated with tumor location, pT stage, lymph node metastasis and clinical stage. Moreover, patients with co-expression of TNC and Twist1 had a poorer prognosis than either TNC or Twist1 positive in GC. Our study revealed that the simultaneous expression of TNC and Twist1 indicated the poorer prognosis of GC. Co-targeting TNC and Twist1 confer significant clinical advantage, which offers a novel therapeutic target in GC.