Accuracy and precision of pseudo-continuous arterial spin labeling perfusion during baseline and hypercapnia: A head-to-head comparison with 15O H2O positron emission tomography
Accuracy and precision of pseudo-continuous arterial spin labeling perfusion during baseline and hypercapnia: A head-to-head comparison with 15O H2O positron emission tomography
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DOI：
10.1016/j.neuroimage.2014.02.011
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发表时间：
2014-05-15
期刊：
影响因子：
5.7
通讯作者：
Nederveen, A. J.
中科院分区：
文献类型：
--
作者：
Heijtel, D. F. R.;Mutsaerts, H. J. M. M.;Nederveen, A. J.
脑血流量(CBF)和脑血管反应性(CVR)的测量提供了有关脑血管状况和局部代谢的有用信息。伪连续动脉自旋标记(PCASL)是一种有前景的无创性MRI技术--用于定量测量CBF，而其他高碳酸血症的pCASL测量目前在定量评估CVR方面显示出巨大的前景。然而，pCASL在更大范围内的引入还有待于进一步评估与黄金标准相比的确切准确度和精密度。O-15H2O正电子发射断层扫描(PET)被认为是目前定量测量CBF和CVR最准确和最精确的方法，但它也是一种更具侵入性的方法之一。因此，在这项研究中，我们评估了基于pCASL的CBF和CVR定量测量的准确性和精密度，方法是与O-15H2O PET进行面对面的比较，基于基线和高碳酸血症期间的定量CBF测量。我们证明，在基线和高碳酸血症期间，pCASL CBF成像相对于O-15H2O PET都是准确的，具有类似的精度。这些结果为pCASL MRI在临床和研究环境中的定量使用铺平了道路。(C)2014 Elsevier Inc.保留所有权利。
Measurements of the cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) provide useful information about cerebrovascular condition and regional metabolism. Pseudo-continuous arterial spin labeling (pCASL) is a promising non-invasive MRI technique-to quantitatively measure the CBF, whereas additional hypercapnic pCASL measurements are currently showing great promise to quantitatively assess the CVR. However, the introduction of pCASL at a larger scale awaits further evaluation of the exact accuracy and precision compared to the gold standard. O-15 H2O positron emission tomography (PET) is currently regarded as the most accurate and precise method to quantitatively measure both CBF and CVR, though it is one of the more invasive methods as well. In this study we therefore assessed the accuracy and precision of quantitative pCASL-based CBF and CVR measurements by performing a head-to-head comparison with O-15 H2O PET, based on quantitative CBF measurements during baseline and hypercapnia. We demonstrate that pCASL CBF imaging is accurate during both baseline and hypercapnia with respect to O-15 H2O PET with a comparable precision. These results pave the way for quantitative usage of pCASL MRI in both clinical and research settings. (c) 2014 Elsevier Inc. All rights reserved.