Comparative effects of therapy with captopril and digoxin in patients with mild to moderate heart failure. The Captopril-Digoxin Multicenter Research Group.
Comparative effects of therapy with captopril and digoxin in patients with mild to moderate heart failure. The Captopril-Digoxin Multicenter Research Group.
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卡托普利和地高辛治疗轻至中度心力衰竭患者的比较效果。
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发表时间：
1988
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影响因子：
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通讯作者：
Kay Petey
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作者：
J. Cohn;M. Hawkins;H. Levine;J. Naughton;E. Rapaport;S. Goldstein;B. Pitt;R. Cody;P. Deedwania;L. Dennick;J. Franciosa;M. McGovern;J. J. Meyer;A. Gradman;B. Massie;M. Packer;J. Doherty;J. Gammill;W. Cooper;S. Engel;R. Fand;Barbara G. Hallows;L. Kerwin;Debra A. Soltesz;J. Parker;K. Lahey;E. Carbajal;P. Watson;R. Dibianco;J. Ronan;D. J. Donohue;K. Lindgren;L. Larca;J. Freitag;Donna Lindemuth;J. Lakier;H. Rosman;M. Włodkowski;R. Cody;S. Kubo;M. Clark;Kathleen Pondolfino;M. Wilén;Drexel Jordan;S. Das;J. Nicklas;Mary Kay Foley;M. Higginbotham;F. Cobb;Jean D. Wilson;D. Berkson;D. Obradovic;P. Hershinow;N. Nicholls;H. Ikram;I. Crozier;C. Pepine;John Culp;M. Limacher;Kathy Mulvehill;D. Farnham;Dorothy Adams;Norene Streicher;C. Shanley;M. Greenberg;J. Strain;M. Hewitt;Barbara Levine;D. Sharpe;R. Briant;R. Coxon;J. Cornyn;N. Topić;H. Willens;Denise Antonishen;D. Reinstein;H. Colfer;Karen E Graham;G. M. Perlow;H. Zarren;B. Bent;Marjorie Zicherman;B. Zaret;Deborah Lawrason;Pat Tellier;Kathy O'Keefe;S. Mohiuddin;L. Stengel;J. Madison;N. Carruthers;F. Elijovich;M. J. O'Sullivan;U. Elkayam;S. Rahimtoola;L. Weber;S. Gottlieb;Carol L. Brown;M. Jessup;S. Ulrich;Jane Kronenthal;D. Capaccio;Colin Grant;E. Gillie;Pat Wood;F. Fouad;Kay Petey
这项多中心、双盲、安慰剂对照研究比较了轻度至中度心力衰竭患者维持利尿治疗期间卡托普利治疗与地高辛治疗的效果。与安慰剂相比，卡托普利治疗显着改善了运动时间（平均增加 82 秒 vs 35 秒）并改善了纽约心脏协会分级（41% vs 22%），但地高辛治疗却没有。与卡托普利治疗（增加 1.8%）和安慰剂（增加 0.9%）相比，地高辛治疗增加射血分数（增加 4.4%）。对于每小时室性早搏超过 10 次的患者，卡托普利组的室性早搏次数减少了 45%，地高辛组则增加了 4%。与接受任一活性药物的患者相比，接受安慰剂的患者治疗失败、利尿治疗需求增加和住院的频率明显更高。使用卡托普利时更容易发生暂时性低血压。卡托普利治疗明显比安慰剂更有效，对于正在接受利尿维持治疗的轻至中度心力衰竭患者来说，卡托普利治疗可替代地高辛治疗。
This multicenter, double-blind, placebo-controlled study compares the effects of captopril treatment with those of digoxin treatment during maintenance diuretic therapy in patients with mild to moderate heart failure. Compared with placebo, captopril therapy resulted in significantly improved exercise time (mean increase, 82 s vs 35 s) and improved New York Heart Association class (41% vs 22%), but digoxin therapy did not. Digoxin treatment increased ejection fraction (4.4% increase) compared with captopril therapy (1.8% increase) and placebo (0.9% increase). The number of ventricular premature beats decreased 45% in the captopril group and increased 4% in the digoxin group in patients with more than ten ventricular premature beats per hour. Treatment failures, increased requirements for diuretic therapy, and hospitalizations were significantly more frequent in patients receiving placebo compared with those receiving either active drug. Transitory hypotension occurred more frequently with administration of captopril. Captopril treatment is significantly more effective than placebo and is an alternative to digoxin therapy in patients with mild to moderate heart failure who are receiving diuretic maintenance therapy.