Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH.
Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH.
复制标题
NLRP3 炎症小体在 NAFLD 进展为 NASH 中的作用
DOI：
10.1155/2016/6489012
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发表时间：
2016
影响因子：
2.7
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Wan X;Xu C;Yu C;Li Y
非酒精性脂肪性肝病（NAFLD）已被公认为全球主要的公共卫生问题。非酒精性脂肪性肝炎（NASH）是NAFLD的一种晚期形式，可能进展为肝硬化和肝细胞癌。从NAFLD到NASH的疾病进展的发病机制尚未完全了解。免疫学机制在疾病进展中已被越来越多地认识到，包括先天免疫、适应性免疫、Toll样受体（TLR）信号传导和肠-肝轴的缺陷。NLRP 3炎性体是一种细胞内多蛋白复合物，参与成熟白细胞介素1-β（IL-1β）的产生并诱导代谢性炎症。NLRP 3炎性小体最近已被证明在NASH的进展中起关键作用。本文综述了NLRP 3炎性小体与NASH进展的关系。
Nonalcoholic fatty liver disease (NAFLD) has been recognized as a major public health problem worldwide. Nonalcoholic steatohepatitis (NASH) is an advanced form of NAFLD that may progress to cirrhosis and hepatocellular carcinoma. The pathogenesis of disease progression from NAFLD to NASH has not been fully understood. Immunological mechanisms that have been increasingly recognized in the disease progression include defects in innate immunity, adaptive immunity, Toll-like receptor (TLR) signaling, and gut-liver axis. The NLRP3 inflammasome is an intracellular multiprotein complex involved in the production of mature interleukin 1-beta (IL-1β) and induces metabolic inflammation. NLRP3 inflammasome has been recently demonstrated to play a crucial role in the progression of NASH. This review highlights the recent findings linking NLRP3 inflammasome to the progression of NASH.