The current landscape of the mesenchymal stromal cell secretome: A new paradigm for cell-free regeneration.
The current landscape of the mesenchymal stromal cell secretome: A new paradigm for cell-free regeneration.
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DOI：
10.1016/j.jcyt.2015.10.008
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发表时间：
2016-01
期刊：
影响因子：
4.5
通讯作者：
Pal R
中科院分区：
文献类型：
--
作者：
Konala VB;Mamidi MK;Bhonde R;Das AK;Pochampally R;Pal R
间充质基质/干细胞（MSC）自我更新的独特性质和它们的多潜能性使它们对研究人员和临床医生具有吸引力。除了分化潜能之外，广泛的分泌性营养因子（细胞因子）库（通常称为MSC分泌组）在过去几年中获得了极大的关注，所述分泌性营养因子（细胞因子）表现出多种功能，例如免疫调节、抗炎活性、血管生成和抗凋亡。有足够的证据表明，间充质干细胞参与组织修复和再生的一个重要途径是通过其分泌组。同时，大量的MSC研究集中在MSC分泌组的表征上;这包括可溶性因子和在细胞外囊泡（例如，外来体和微囊泡）中释放的因子。本文综述了我们目前对MSC分泌组的了解及其潜在的临床应用。
The unique properties of mesenchymal stromal/stem cells (MSCs) to self-renew and their multipotentiality have rendered them attractive to researchers and clinicians. In addition to the differentiation potential, the broad repertoire of secreted trophic factors (cytokines) exhibiting diverse functions such as immunomodulation, anti-inflammatory activity, angiogenesis and anti-apoptotic, commonly referred to as the MSC secretome, has gained immense attention in the past few years. There is enough evidence to show that the one important pathway by which MSCs participate in tissue repair and regeneration is through its secretome. Concurrently, a large body of MSC research has focused on characterization of the MSC secretome; this includes both soluble factors and factors released in extracellular vesicles, for example, exosomes and microvesicles. This review provides an overview of our current understanding of the MSC secretome with respect to their potential clinical applications.