The Epitranscriptome of Noncoding RNAs in Cancer.
The Epitranscriptome of Noncoding RNAs in Cancer.
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DOI：
10.1158/2159-8290.cd-16-1292
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发表时间：
2017-04
期刊：
影响因子：
28.2
通讯作者：
Pandolfi PP
中科院分区：
文献类型：
--
作者：
Esteller M;Pandolfi PP
RNA的活性由不同类型的转录后修饰控制，例如甲基的添加和其他化学和结构变化，这些变化最近已通过高通量测序在人类细胞中描述。在此，我们将讨论所谓的epitranscriptome是如何在癌症中被破坏的，以及它的作者，读者和擦除器对细胞转化过程的贡献是什么，特别关注ncRNA的表观遗传修饰。
The activity of RNA is controlled by different types of post-transcriptional modifications, such as the addition of methyl groups and other chemical and structural changes, that have been recently described in human cells by high-throughput sequencing. Herein, we will discuss how the so called epitranscriptome is disrupted in cancer and what the contribution of its writers, readers and erasers to the process of cellular transformation is, particularly focusing in the epigenetic modifications of ncRNAs.