Intraventricular Hemorrhage Due to Coagulopathy After Vitamin K Administration in a Preterm Infant With Maternal Crohn Disease.
Intraventricular Hemorrhage Due to Coagulopathy After Vitamin K Administration in a Preterm Infant With Maternal Crohn Disease.
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DOI：
10.1177/1179670717746333
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Morioka I
中科院分区：
文献类型：
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作者：
Fujioka K;Fukushima S;Nishida K;Iijima K;Morioka I
脑室内出血（IVH）是早产儿的一种毁灭性疾病，可导致不良的神经发育结局。脑室内出血通常发生在出生后72小时内;急性期后IVH（出生后>1周）不常见。胎儿和新生儿止血系统的发育是一个年龄依赖性的进化过程，新生儿止血系统的特征是维生素K依赖性因子水平低，早产导致进一步降低。重要的是，严重的凝血缺陷可能是IVH的主要促成因素。妊娠期活动性母体克罗恩病（CD）通过肠吸收不良引起营养不良;这可能包括维生素K缺乏，导致胎儿维生素K缺乏。我们在此描述一早产儿谁出生的母亲与CD和开发后急性期IVH由于凝血功能障碍，尽管维生素K管理。
Intraventricular hemorrhage (IVH) is a devastating morbidity in preterm infants and can result in poor neurodevelopmental outcomes. Intraventricular hemorrhage usually occurs within 72 hours after birth; post–acute-phase IVH (>1 week after birth) is uncommon. Development of the hemostatic system in fetuses and neonates is an age-dependent evolving process, and the neonatal hemostatic system is characterized by low levels of vitamin K–dependent factors, with further reduction caused by prematurity. Importantly, a severe coagulation deficiency can be a major contributing factor of IVH. Active maternal Crohn disease (CD) during pregnancy causes malnutrition via enteral malabsorption; this may include vitamin K deficiency, resulting in fetal vitamin K deficiency. We herein describe a preterm infant who was born to a mother with CD and developed post–acute-phase IVH due to coagulopathy despite vitamin K administration.