Novel concept for the epaxial/hypaxial boundary based on neuronal development
Novel concept for the epaxial/hypaxial boundary based on neuronal development
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基于神经元发育的轴上/轴下边界的新概念
DOI：
10.1111/joa.13219
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Noboru Sato
中科院分区：
文献类型：
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作者：
Hiroshi Nagashima;Daisuke Koga;Satoshi Kusumi;Katsuki Mukaigasa;Hiroyuki Yaginuma;Tatsuo Ushiki;Noboru Sato
脊椎动物的躯干肌分为背轴上肌和腹轴下肌。轴上肌和轴下肌分别定义为由脊神经的背侧支和腹侧支支配的肌肉。每一簇脊髓运动神经元通过背支支配轴上肌，而在腹支上行进的簇支配轴下肌。在这里，我们表明，一些运动神经元表现出轴上肌肉的分子轮廓遵循的路径在腹侧支。背深肩肌和一些体壁肌肉由于通过腹侧支的神经支配而被定义为轴下肌，但这些腹侧支的一部分具有支配轴上肌的运动神经元的分子特征。因此，轴上和轴下边界不能简单地由脊神经的分支模式来确定。我们认为，虽然肌肉神经支配发生通过腹侧支，背深肩肌和一些体壁肌肉代表一个中间组，位于轴上和轴下肌肉之间。
Trunk muscles in vertebrates are classified as either dorsal epaxial or ventral hypaxial muscles. Epaxial and hypaxial muscles are defined as muscles innervated by the dorsal and ventral rami of spinal nerves, respectively. Each cluster of spinal motor neurons passing through dorsal rami innervates epaxial muscles, whereas clusters traveling on the ventral rami innervate hypaxial muscles. Herein, we show that some motor neurons exhibiting molecular profiles for epaxial muscles follow a path in the ventral rami. Dorsal deep‐shoulder muscles and some body wall muscles are defined as hypaxial due to innervation via the ventral rami, but a part of these ventral rami has the molecular profile of motor neurons that innervate epaxial muscles. Thus, the epaxial and hypaxial boundary cannot be determined simply by the ramification pattern of spinal nerves. We propose that, although muscle innervation occurs via the ventral rami, dorsal deep‐shoulder muscles and some body wall muscles represent an intermediate group that lies between epaxial and hypaxial muscles.