Gene expression pattern tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish
Gene expression pattern tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish
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发表时间：
2000
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通讯作者：
D. Ahn;I. Ruvinsky;Andrew C. Oates;Lee M. Silver;Robert K. Ho
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作者：
D. Ahn;I. Ruvinsky;Andrew C. Oates;Lee M. Silver;Robert K. Ho
T-box基因是一个转录调控基因家族，参与了从胚层形成到中枢神经系统区域化的多种发育过程。在这篇报告中，我们描述了一个新的斑马鱼T-box基因的克隆和表达模式，我们命名为tbx 20。tbx 20是从不同门的动物中分离的另外两个T-box基因的直系同源物-黑腹果蝇的H15和秀丽隐杆线虫的tbx-12，表明该基因的进化起源早于原口动物和后口动物之间的分歧。在发育过程中，tbx 20在中胚层和外胚层起源的胚胎结构中表达，包括心脏、颅运动神经元和背主动脉的顶部。q 2000爱思唯尔科学爱尔兰有限公司保留所有权利。
The T-box genes constitute a family of transcriptional regulator genes that have been implicated in a variety of developmental processes ranging from the formation of germ layers to the regionalization of the central nervous system. In this report we describe the cloning and expression pattern of a new T-box gene from zebrafish, which we named tbx20. tbx20 is an ortholog of two other T-box genes isolated from animals of different phyla ‐ H15 of Drosophila melanogaster and tbx-12 of Caenorhabditis elegans, suggesting that the evolutionary origin of this gene predates the divergence between the protostomes and deuterostomes. During development, tbx20 is expressed in embryonic structures of both mesodermal and ectodermal origins, including the heart, cranial motor neurons, and the roof of the dorsal aorta. q 2000 Elsevier Science Ireland Ltd. All rights reserved.