Effects of Duration and Midpoint of Sleep on Corticolimbic Circuitry in Youth.
Effects of Duration and Midpoint of Sleep on Corticolimbic Circuitry in Youth.
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DOI：
10.1177/2470547019856332
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Rabinak, Christine A
中科院分区：
文献类型：
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作者：
Hehr, Aneesh;Marusak, Hilary A;Rabinak, Christine A
简介：充足的睡眠对认知和情绪相关功能至关重要，建议6至12岁的儿童睡眠9至12小时，13至18岁的儿童睡眠8至10小时。然而，全国调查数据表明，老年人睡眠时间少于年轻人，入睡时间也比年轻人晚。睡眠持续时间和时间的这种变化与情绪相关问题（例如，焦虑、抑郁）。鉴于睡眠时间和时间都与情绪相关的结果有关，本研究测试了睡眠时间和时间以及它们的相互作用对儿童和青少年皮质边缘情绪相关神经回路的静息状态功能连接（RS-FC）的影响。共有63名儿童和青少年（6-17岁，34名女性）完成了周末过夜睡眠日记和第二天（周日）10分钟静息状态功能磁共振成像扫描。计算杏仁核的全脑RS-FC，并研究睡眠持续时间、时间（即，结果：总的来说，我们发现老年人比年轻人睡得更晚，睡得更少。控制年龄，较短的睡眠时间与较低的RS-FC杏仁核和涉及情绪调节的区域，包括腹前扣带皮层，中央前回，和上级颞回。有趣的是，睡眠中点与一组参与内感受和感觉处理的不同大脑区域的连接性改变有关，这些区域包括小脑、边缘上回和中央后回。我们的数据还表明，广泛的互动影响的睡眠持续时间和中点的大脑区域牵连在情绪调节，感觉处理，和电机control.CONCLUSION：这些结果表明，睡眠持续时间和中点的睡眠与第二天RS-FC内皮质边缘情感相关的神经回路在儿童和青少年。观察到的睡眠持续时间和时间对RS-FC的相互作用可能反映了稳态和昼夜节律过程如何在大脑中相互作用，并解释了在考虑睡眠持续时间和时间时观察到的情绪健康方面的复杂模式。皮质边缘回路中与睡眠相关的变化可能会导致青春期出现与情绪相关的问题。
INTRODUCTION: Adequate sleep is essential for cognitive and emotion-related functioning, and 9 to 12 hr of sleep is recommended for children ages 6 to 12 years and 8 to 10 hr for children ages 13 to 18 years. However, national survey data indicate that older youth sleep for fewer hours and fall asleep later than younger youth. This shift in sleep duration and timing corresponds with a sharp increase in onset of emotion-related problems (e.g., anxiety, depression) during adolescence. Given that both sleep duration and timing have been linked to emotion-related outcomes, the present study tests the effects of sleep duration and timing, and their interaction, on resting-state functional connectivity (RS-FC) of corticolimbic emotion-related neural circuitry in children and adolescents.METHODS: A total of 63 children and adolescents (6-17 years, 34 females) completed a weekend overnight sleep journal and a 10-min resting-state functional magnetic resonance imaging scan the next day (Sunday). Whole-brain RS-FC of the amygdala was computed, and the effects of sleep duration, timing (i.e., midpoint of sleep), and their interaction were explored using regression analyses.RESULTS: Overall, we found that older youth tended to sleep later and for fewer hours than younger youth. Controlling for age, shorter sleep duration was associated with lower RS-FC between the amygdala and regions implicated in emotion regulation, including ventral anterior cingulate cortex, precentral gyrus, and superior temporal gyrus. Interestingly, midpoint of sleep was associated with altered connectivity in a distinct set of brain regions involved in interoception and sensory processing, including insula, supramarginal gyrus, and postcentral gyrus. Our data also indicate widespread interactive effects of sleep duration and midpoint on brain regions implicated in emotion regulation, sensory processing, and motor control.CONCLUSION: These results suggest that both sleep duration and midpoint of sleep are associated with next-day RS-FC within corticolimbic emotion-related neural circuitry in children and adolescents. The observed interactive effects of sleep duration and timing on RS-FC may reflect how homeostatic and circadian process interact in the brain and explain the complex patterns observed with respect to emotional health when considering sleep duration and timing. Sleep-related changes in corticolimbic circuitry may contribute to the onset of emotion-related problems during adolescence.