Consensus statement on peritoneal mesothelioma
Consensus statement on peritoneal mesothelioma
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DOI：
10.1002/jso.21055
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发表时间：
2008-09-15
影响因子：
2.5
通讯作者：
Baratti, Dario
中科院分区：
文献类型：
--
作者：
Deraco, Marcello;Bartlett, David;Baratti, Dario
弥漫性恶性腹膜间皮瘤(DMPM)传统上被认为是一种快速致死性疾病。最近，几项独立的前瞻性试验报告称，采用强化的局部区域治疗策略，包括细胞减少性手术(CRS)和围手术期的腹膜内化疗(PIC)，可提高生存率。然而，大多数外科数据来自单一机构的I期或II期研究，在纳入标准、细胞减少手术程序、药物、温度和热化疗的输送方法(开腹与闭合)方面存在广泛的变异性。这份手稿批判性地分析和讨论了一组医疗保健提供者的结果，这些提供者试图在这组患者的管理中达成共识声明。关于术前评估、患者资格、综合治疗方法、术后随访和未来研究前景的主要冲突点被总结为一系列多项选择题。在“第五届国际腹膜表面恶性肿瘤研讨会”的网站上放置调查问卷，小组成员通过互联网进行投票。在讲习班专门举行的一次会议上提交了结果供进一步辩论。确定了一般治疗指南和未来的研究前景。
Diffuse malignant peritoneal mesothelioma (DMPM) has been traditionally regarded as a rapidly lethal disease. Recently, several independent prospective trials have reported improved survival with an intensive loco-regional treatment strategy including cytoreductive surgery (CRS) along with peri-operative intra-peritoneal chemotherapy (PIC). However, most of the surgical data comes from mono-institutional phase I or II studies and there is a broad range of variability regarding inclusion criteria, cytoreductive surgical procedures, drugs, temperatures and methods of delivering the heated chemotherapy (open vs. closed abdomen). This manuscript critically analyze and discuss the results of a group of health care providers trying to achieve a consensus statement in the management of this group of: patients. The main conflicting points regarding preoperative evaluation, patient eligibility, combined treatment methodology, postoperative follow-up and future investigational perspectives were summarized as a list of multiple-choice questions. A questionnaire was placed on the website of the "5(th) International Workshop on Peritoneal Surface Malignancies" and the group members voted via internet. The results were presented for further debate during a dedicated session of the Workshop. The general treatment guidelines and future investigational perspectives were defined.