Clinical evaluation of CO2 laser vaporization therapy for oral lichen planus: a single-arm intervention study.
Clinical evaluation of CO2 laser vaporization therapy for oral lichen planus: a single-arm intervention study.
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CO2 激光汽化治疗口腔扁平苔藓的临床评价：单臂干预研究。
DOI：
10.1089/photob.2018.4559
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Komori T.
中科院分区：
文献类型：
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作者：
Matsumoto K;Matsuo K;Yatagai N;Enomoto Y;Shigeoka M;Hasegawa T;Suzuki H;Komori T.
目的：评价CO2激光雾化治疗保守治疗无效的口腔扁平苔藓(OLP)的疗效。他们接受了为期3个月的保守治疗，使用的是肾上腺皮质激素软膏和氢氧化氮磺酸钠含漱液。保守治疗无效的患者接受CO2激光雾化治疗(3 W，连续波模式)。使用数字评定量表(NRS)作为主观指标，Thongprasom Sign Score(TSS)作为OLP的客观指标进行评估。在治疗前、治疗后7天、1、3、6个月和1年后的检查中记录这两个量表。用Wilcoxon‘s符号等级检验检验照射前后各时间点的差异。结果：9例患者共11个部位接受激光照射。放疗后1年，11个部位(100%)和10个部位(90.9%)的NRS评分和TSS评分均较照射前降低。放疗后1个月、3个月(短期)、6个月和1年(中远期)的神经功能障碍评分和症状自评量表评分均显著低于放疗前(p<； )。结论：这些单臂临床试验结果显示了CO2激光雾化治疗难治性口腔扁平苔藓的疗效。
Objective:The purpose of this study is to evaluate the efficacy of CO2laser vaporization therapy for oral lichen planus (OLP) refractory to conservative treatments.Methods:The study group comprised 16 patients with clinically and histologically diagnosed OLP. They underwent conservative treatment for 3 months using an adrenal cortex hormone ointment and azulene sulfonate sodium hydrate gargle. Patients who showed no improvement with conservative treatment underwent CO2laser vaporization therapy (3 W, continuous-wave mode). The assessment was performed using the numerical rating scale (NRS) as a subjective indicator and the Thongprasom sign score (TSS) as an objective indicator of OLP. These two scales were recorded during examinations performed before treatment and then at 7 days, 1, 3, and 6 months, and 1 year after irradiation. Differences between preirradiation and each point of time after irradiation were tested by Wilcoxon's signed-rank tests.Results:Laser irradiation was administered to 9 patients with 11 sites. The NRS score and TSS decreased at all 11 sites (100%) and 10 sites (90.9%) at 1 year after irradiation compared with preirradiation scores. The NRS score and TSS were statistically lower (p< 0.05) at 1 and 3 months (short-term) and 6 months and 1 year (mid-long-term) after irradiation than the preirradiation scores. There were no patients with malignant transformation during the study period.Conclusions:These single-arm clinical trial results show the efficacy of CO2laser vaporization therapy for OLP refractory to conservative treatment.