Distinctive morphology of hippocampal CA1 terminations in orbital and medial frontal cortex in macaque monkeys
Distinctive morphology of hippocampal CA1 terminations in orbital and medial frontal cortex in macaque monkeys
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DOI：
10.1007/s00221-005-0187-7
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发表时间：
2006-03
影响因子：
2
通讯作者：
Y. Zhong;M. Yukie;K. Rockland
中科院分区：
文献类型：
--
作者：
Y. Zhong;M. Yukie;K. Rockland
用顺行示踪剂在两只猕猴的CA1区观察了海马区与眶和内侧额叶皮质(OMFC)连接的精细形态。轴突主要终止于第11、13、14c、25和32区的第2层和第3层，在这些层内分布广泛，横跨2-4 mm。环状突沿主轴突散在分布，但也以独特的小球状终末簇状出现(“迷你团”；直径50μm)。在第3层中偶尔观察到较大的末端乔木，这些乔木通常是异常曲折或缠绕的。这些特征可能暗示了海马-OMFC连接的特殊微电路，包括来自特定CA1投射神经元亚群的来源。
The fine morphology of hippocampal connections to the orbital and medial frontal cortex (OMFC) was investigated by placing injections of anterograde tracers in the CA1 in two monkeys. The axons terminated mainly in layers 2 and 3, of areas 11, 13, 14c, 25, and 32, and were widely divergent in these layers, traversing 2–4 mm. Boutons were scattered along the main axon, but also occurred as distinctive small, spherical clusters of terminations (“mini-clusters”; diameter <50 μm). Occasional larger terminal arbors were observed in layer 3 and these were often unusually tortuous or convoluted. These features may imply a specialized microcircuitry of hippocampal-OMFC connections, including an origin from a particular subpopulation of CA1 projection neurons.