A developmental functional MRI study of prefrontal activation during performance of a Go-No-Go task
A developmental functional MRI study of prefrontal activation during performance of a Go-No-Go task
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DOI：
10.1162/jocn.1997.9.6.835
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发表时间：
1997-11-01
影响因子：
3.2
通讯作者：
Rapoport, JL
中科院分区：
文献类型：
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作者：
Casey, BJ;Trainor, RJ;Rapoport, JL
本研究采用功能磁共振成像（fMRI）技术，探讨了前额叶皮层在执行Go-No-Go范式时激活模式的重要发展差异。18名受试者（9名儿童和9名成人）在执行反应抑制任务期间使用梯度回波、回波平面成像进行扫描。研究结果提出了四个一般性发现。首先，儿童和成人的前额叶皮层激活的位置没有不同，这与我们早期在工作记忆任务期间前额叶激活的儿科fMRI结果相似（凯西等人，1995年）。第二，儿童的激活量明显大于成人。这些激活量的差异主要在背侧和外侧前额叶皮质中观察到。第三，虽然抑制过程通常与更多的腹侧或眶额区相关，但目前的研究显示，激活分布在背外侧和眶额皮质。最后，与动物和人类病变研究一致，眶额叶和前扣带皮层的活动与行为表现相关（即，假警报的数量）。这些结果进一步证明了这种方法在研究儿科人群中的实用性。
This study examines important developmental differences in patterns of activation in the prefrontal cortex during performance of a Go-No-Go paradigm using functional magnetic resonance imaging (fMRI). Eighteen subjects (9 children and 9 adults) were scanned using gradient echo, echo planar imaging during performance of a response inhibition task. The results suggest four general findings. First, the location of activation in the prefrontal cortex was not different between children and adults, which is similar to our earlier pediatric fMRI results of prefrontal activation during a working memory task (Casey et al., 1995). Second, the volume of activation was significantly greater for children relative to adults. These differences in volume of activation were observed predominantly in the dorsal and lateral prefrontal cortices. Third, although inhibitory processes have typically been associated with more ventral or orbital frontal regions, the current study revealed activation that was distributed across both dorsolateral and orbitofrontal cortices. Finally, consistent with animal and human lesion studies, activity in orbital frontal and anterior cingulate cortices correlated with behavioral performance (i.e., number of false alarms). These results further demonstrate the utility of this methodology in studying pediatric populations.