Species-specific temperature sensitivity of TRPA1.
Species-specific temperature sensitivity of TRPA1.
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DOI：
10.1080/23328940.2014.1000702
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发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
Gracheva EO
中科院分区：
文献类型：
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作者：
Laursen WJ;Anderson EO;Hoffstaetter LJ;Bagriantsev SN;Gracheva EO
瞬时受体电位锚蛋白1（TRPA 1）是一种对温度和化学刺激敏感的多模态离子通道。温度和令人厌恶的化学检测对生存的重要性推动了TRPA1敏感性的进化多样性。这种多样性可以在不同物种中的TRPA1的各种作用中观察到，其中建议作为温度不敏感的化学传感器，热换能器，有害的冷换能器或用于猎物定位的低强度热的检测器。探索物种间TRPA1功能的变化提供了对微调热和化学敏感性的分子机制的进化见解，并提供了解决离子通道温度门控基本原理的机会。十年的研究已经产生了许多假说，描述了TRPA1的生理作用，其活动的调节剂，以及门控的生物物理原理。本文综述了TRPA1在进化过程中的多样性，并探讨了TRPA1激活的可能机制。
Transient receptor potential ankyrin 1 (TRPA1) is a polymodal ion channel sensitive to temperature and chemical stimuli. The importance of temperature and aversive chemical detection for survival has driven the evolutionary diversity of TRPA1 sensitivity. This diversity can be observed in the various roles of TRPA1 in different species, where it is proposed to act as a temperature-insensitive chemosensor, a heat transducer, a noxious cold transducer, or a detector of low-intensity heat for prey localization. Exploring the variation of TRPA1 functions among species provides evolutionary insight into molecular mechanisms that fine-tune thermal and chemical sensitivity, and offers an opportunity to address basic principles of temperature gating in ion channels. A decade of research has yielded a number of hypotheses describing physiological roles of TRPA1, modulators of its activity, and biophysical principles of gating. This review surveys the diversity of TRPA1 adaptations across evolutionary taxa and explores possible mechanisms of TRPA1 activation.