RECOMBINANT HUMAN INSULIN-LIKE GROWTH FACTOR-I STIMULATES GROWTH AND HAS DISTINCT EFFECTS ON ORGAN SIZE IN HYPOPHYSECTOMIZED RATS
RECOMBINANT HUMAN INSULIN-LIKE GROWTH FACTOR-I STIMULATES GROWTH AND HAS DISTINCT EFFECTS ON ORGAN SIZE IN HYPOPHYSECTOMIZED RATS
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DOI：
10.1073/pnas.85.13.4889
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发表时间：
1988-07-01
影响因子：
11.1
通讯作者：
FROESCH, ER
中科院分区：
文献类型：
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作者：
GULER, HP;ZAPF, J;FROESCH, ER
将重组人胰岛素样生长因子-I(rhIGF-I)注入去垂体大鼠的皮下，长达18天。每天服用300微克(39nmol)的重组人胰岛素样生长因子-I(rhIGF-I)和每天服用200毫克(4.5nmol)的人生长激素(HGH)，同样可以增加体重、胫骨骨骺宽度、纵向骨生长和骨小梁形成。然而，肾和脾的重量增加，重组人IGF-I组大于hGH组，而附睾脂肪垫的重量则减轻。经重组人胰岛素样生长因子-I治疗后，胸腺重量增加。因此，长期给予胰岛素样生长因子-I可模拟垂体切除大鼠的生长激素效应。在器官重量方面，rhIGF-I和hGH治疗之间的数量差异可能与不同形式的循环IGF-I有关，也可能是由于GH和IGF-I的独立作用所致。研究结果支持生长抑素假说，但也强调了生长激素作为IGF-I调节因子的作用。
Recombinant human insulin-like growth factor I (rhIGF-I) was infused subcutaneously into hypophysectomized rats for as long as 18 days. Three hundred micrograms (39 nmol) of rhIGF-I per day and 200 milliunits (4.5 nmol) of human growth hormone (hGH) per day increased body weight, tibial epiphyseal width, longitudinal bone growth, and trabecular bone formation similarly. Weight gains of the kidneys and spleen, however, were greater with rhIGF-I than with hGH, whereas the weight of the epididymal fat pads was reduced with rhIGF-I. The weight of the thymus was increased by rhIGF-I treatment. Thus, IGF-I administered over a prolonged period of time mimics GH effects in hypophysectomized rats. Quantitative differences between rhIGF-I and hGH treatment with respect to organ weights may be related to different forms of circulating IGF-I or may be due to independent effects of GH and IGF-I. The results support the somatomedin hypothesis, but they also stress the role of GH as a modulator of IGF-I action.