Antral release of gastrin and somatostatin in duodenal ulcer and control subjects.
Antral release of gastrin and somatostatin in duodenal ulcer and control subjects.
复制标题
十二指肠溃疡和对照受试者胃泌素和生长抑素的胃窦释放。
作者：
Harty,RF;Maico,DG;McGuigan,JE
用器官培养法比较十二指肠溃疡患者和非溃疡患者胃窦粘膜的胃泌素和生长抑素的释放。有十二指肠溃疡病史患者的胃窦黏膜外植体在二丁基环AMP(DBCAMP)作用下，胃窦胃泌素的释放比例高于非溃疡患者的胃窦黏膜外植体。十二指肠溃疡患者胃窦粘膜释放的生长抑素明显少于非溃疡患者胃窦组织释放的生长抑素。在非溃疡组，胃窦生长抑素和胃泌素释放到培养液中的量呈正相关(r=0.64，小于p0.01)。十二指肠球部溃疡患者胃泌素释放与胃窦粘膜生长抑素释放无相关性(r=0.09，p>0.2)。这些研究的结果表明，十二指肠溃疡患者胃窦粘膜对刺激的反应胃泌素释放增加，而生长抑素释放减少。十二指肠溃疡患者胃窦生长抑素和胃泌素旁分泌关系的改变可能至少部分参与了十二指肠溃疡的发病机制。
Organ culture was used to compare gastrin and somatostatin release from cultured antral mucosa obtained from duodenal ulcer and non-ulcer (control) subjects. In response to dibutyryl cyclic AMP (DBCAMP) cultured antral mucosal explants from patients with a history of duodenal ulcer released a greater proportion of antral gastrin into the medium than did antral mucosal explants from non-ulcer subjects. Somatostatin release from antral mucosa from duodenal ulcer patients was substantially less than somatostatin released by antral explants from non-ulcer subjects. In the non-ulcer subjects there was a direct positive correlation between the amounts of antral somatostatin and gastrin released into the culture medium (r = 0.64, less than p 0.01). In the duodenal ulcer patients, however, there was no correlation between gastrin release and somatostatin release from antral mucosa ( r = 0.09; p greater than 0.2). Results of these studies identify enhanced gastrin release in response to stimulation and decreased release of somatostatin from antral mucosa of duodenal ulcer patients. These alterations in paracrine relationships of antral somatostatin and gastrin in duodenal ulcer subjects may contribute, at least in part, to the pathogenesis of duodenal ulcer disease.