The effect of ageing on retinal nerve fibre layer thickness: an evaluation by scanning laser polarimetry with variable corneal compensation
The effect of ageing on retinal nerve fibre layer thickness: an evaluation by scanning laser polarimetry with variable corneal compensation
复制标题
DOI：
10.1111/j.1600-0420.2006.00655.x
复制
发表时间：
2006-06-01
期刊：
影响因子：
--
通讯作者：
Ravalico, Giuseppe
中科院分区：
文献类型：
--
作者：
Da Pozzo, Stefano;Iacono, Pierluigi;Ravalico, Giuseppe
目的：评价采用带可变角膜补偿的扫描激光偏振仪(GDX-VCC)对324名健康受试者(平均年龄56+/-14岁，21~85岁)进行全面的眼科检查、标准自动视野检查和RNFL扫描，以评估与年龄相关的视网膜神经纤维层(RNFL)的明显变薄。收集打印输出中提供的时间-上-鼻-下-时间(TSNIT)、上、下平均值(SA和IA)，并计算所有眼睛的平均值，以及按性别和年龄十年分开眼睛后的平均值。结果：3个参数值与年龄呈显著正相关(TSNIT、SA和IA每年分别为0.08亩、0.16亩和0.12亩；p<；0.001)。分析表明，年龄与十岁也有类似的关联(ANOVA上的P<；0.001)。对于TSNIT的平均值，估计65岁的寿命比基准值薄9.5%。SA和IA的对应值分别为16.2%和11.7%。结论：GDX-VCC分析证实了先前关于RNFL显著变薄的报道。然而，发现了较低的年增长率，可能是因为GDX-VCC测量比上一代偏振仪获得的更可靠。
Purpose: To evaluate whether a significant age-related thinning of the retinal nerve fibre layer (RNFL) is measurable by means of scanning laser polarimetry with variable corneal compensation (GDx-VCC) in a sample of healthy eyes.Methods: A sample of 324 eyes of 324 healthy subjects (mean age 56 +/- 14 years, range 21-85 years) underwent a complete ophthalmic evaluation, standard automated perimetry and RNFL scan with the GDx-VCC. Temporal-superior-nasal-inferior-temporal (TSNIT), superior and inferior average (SA and IA) values provided on the printout were collected and their mean value averaged from all eyes and also after separating the eyes by gender and by age decades. The values of the three parameters were plotted against age and linear regression was calculated.Results: Ageing is associated with a significant RNFL thinning (0.08 mu, 0.16 mu and 0.12 mu per year for TSNIT, SA and IA, respectively; p < 0.001). Analysis showed a similar association with age decade (p < 0.001 on anova). For the TSNIT average, a 9.5% thinning from baseline values was estimated for a 65-year lifespan. Corresponding values for SA and IA were 16.2% and 11.7%, respectively.Conclusions: Analysis by GDx-VCC confirmed previous reports about significant age-related RNFL thinning. However, a lower rate per year was found, probably because GDx-VCC measurements are much more reliable than those obtained with the previous generation of polarimeters.