Schistosoma japonicum eggs modulate the activity of CD4+ CD25+ Tregs and prevent development of colitis in mice
Schistosoma japonicum eggs modulate the activity of CD4+ CD25+ Tregs and prevent development of colitis in mice
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DOI：
10.1016/j.exppara.2007.02.009
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发表时间：
2007-08-01
影响因子：
2.1
通讯作者：
Li, Yong-long
中科院分区：
文献类型：
--
作者：
Mo, Hong-mei;Liu, Wen-qi;Li, Yong-long
克罗恩病 (CD) 被认为是由免疫系统紊乱引起的，蠕虫感染可能与该疾病的发展相互作用。我们用三硝基苯磺酸（TNBS）诱导小鼠结肠炎，并观察腹腔注射日本血吸虫虫卵对病程的影响。注射鸡蛋后，经鸡蛋处理的小鼠结肠炎症减轻，体外培养的脾细胞分泌的 IFN-γ（一种 Th1 细胞因子）受到极大抑制，IL-4、IL-5 和 IL-10（Th2 细胞因子）的分泌显着升高。此外，与未接触鸡蛋的动物相比，患有 TNBS 诱导结肠炎的接触鸡蛋的小鼠脾脏中调节性 T 细胞 (Treg) 的百分比有所增加。数据表明，Tregs可能被日本血吸虫卵激活，并在恢复TNBS诱导的小鼠结肠炎的免疫紊乱中发挥作用。 (c) 2007 Elsevier Inc. 保留所有权利。
Crohn's disease (CD) is considered to be caused by a disorder of the immune system and helminth infections may interact with development of the disease. We induced colitis in mice by trinitrobenzenesulfonic acid (TNBS) and observed the effects of intraperitoneally injected eggs of Schistosoma japonicum on the course of the disease. The inflammation in the colon was reduced in egg-treated mice and secretion of IFN-gamma (a Th1 cytokine) by cultured spleen cells in vitro was greatly suppressed, and of IL-4, IL-5 and IL-10 (Th2 cytokines) significantly elevated after egg injection. Also, the percentage of regulatory T-cells (Tregs) was increased in the spleens of egg-exposed mice with TNBS-induced colitis compared to non-egg exposed animals. The data suggest that Tregs may be activated by S. japonicum eggs and play a role in restoring immune disorders in TNBS-induced colitis of mice. (c) 2007 Elsevier Inc. All rights reserved.