Proteostasis and aging
Proteostasis and aging
复制标题
DOI：
10.1038/nm.4001
复制
发表时间：
2015-12-01
期刊：
影响因子：
82.9
通讯作者：
Cuervo, Ana Maria
中科院分区：
文献类型：
--
作者：
Kaushik, Susmita;Cuervo, Ana Maria
细胞内损伤的累积几乎是衰老的普遍标志。对有助于细胞蛋白质质量控制的系统的更好理解揭示了衰老细胞中蛋白质组对压力的脆弱性增加的原因。蛋白质稳态或蛋白质稳态的维持是通过精确协调的系统来实现的，这些系统迅速纠正不需要的蛋白质组学变化。在这里，我们专注于最近的发展，突出了蛋白质稳态网络的多维性，它允许协调蛋白质稳态细胞内，细胞之间，甚至跨器官，以及它们如何影响常见的年龄相关疾病时，他们在老化故障。
Accumulation of intracellular damage is an almost universal hallmark of aging. An improved understanding of the systems that contribute to cellular protein quality control has shed light on the reasons for the increased vulnerability of the proteome to stress in aging cells. Maintenance of protein homeostasis, or proteostasis, is attained through precisely coordinated systems that rapidly correct unwanted proteomic changes. Here we focus on recent developments that highlight the multidimensional nature of the proteostasis networks, which allow for coordinated protein homeostasis intracellularly, in between cells and even across organs, as well as on how they affect common age-associated diseases when they malfunction in aging.