Plasma‐Amino Acid Profiles in Sepsis and Stress
Plasma‐Amino Acid Profiles in Sepsis and Stress
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脓毒症和应激状态下的血浆氨基酸谱
DOI：
10.1097/00000658-198901000-00009
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发表时间：
1989
影响因子：
9
通讯作者：
P. Soeters
中科院分区：
文献类型：
--
作者：
J. P. Vente;M. V. von Meyenfeldt;H. van Eijk;C. V. Van Berlo;D. Gouma;C. J. van der Linden;P. Soeters
脓毒症与特定的血浆氨基酸模式有关。对65例患者进行了前瞻性调查，以确定这些模式是否确实是败血症特异性的，或者是代谢应激特异性的，而不伴有败血症，或者与器官衰竭的存在有关。几乎所有氨基酸水平均降低了10 ~ 30% (p < 0.05)，而胱氨酸和苯丙氨酸水平显著升高。这些变化在严重脓毒症中更为明显。器官衰竭与氨基酸谱的显著改变无关。没有发现脓毒症和没有脓毒症迹象的应激之间的差异。此外，即将死亡与异常氨基酸谱无关。我们得出结论，败血症和代谢应激与血浆氨基酸谱的变化有关，但这种变化是特异性的，因此不能作为疾病严重程度的指标。
Sepsis has been associated with specific plasma amino acid patterns. Sixty-five patients were prospectively investigated as to whether these patterns are indeed sepsis specific, or specific for metabolic stress without concomitant sepsis, or associated with the presence of organ failure. Virtually all aminoacid levels were decreased by 10–30% (p < 0.05), whereas cystine and phenyl-alanine were significantly elevated. These changes were more pronounced in severe sepsis. Organ failure was not associated with significantly altered amino acid profiles. No differences were found between sepsis and stress without signs of sepsis. In addition, imminent death was not associated with aberrant amino acid profiles. We conclude that sepsis and metabolic stress are associated with changes in plasma amino acid profiles, but that such changes are aspeciflc and therefore poor indicators of disease severity.