Astaxanthin ameliorates features of metabolic syndrome in SHR/NDmcr-cp
Astaxanthin ameliorates features of metabolic syndrome in SHR/NDmcr-cp
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DOI：
10.1016/j.lfs.2006.09.041
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发表时间：
2007-01-16
期刊：
影响因子：
6.1
通讯作者：
Watanabe, Hiroshi
中科院分区：
文献类型：
--
作者：
Hussein, Ghazi;Nakagawa, Takako;Watanabe, Hiroshi
糖脂代谢指标在代谢综合征及其胰岛素抵抗的主要特征中起着重要作用。本研究旨在研究膳食虾青素油（ASX-O）是否对SHR/NDmcr-cp（cp/cp）大鼠模型的代谢综合征特征具有潜在影响。口服ASX（50 mg/kg/天）22周可显著降低SHRcp的动脉血压。并能显著降低空腹血糖水平、胰岛素抵抗稳态指数（HOMA-IR），改善胰岛素敏感性。结果还显示脂联素水平改善，高密度脂蛋白胆固醇显著增加，甘油三酯和非酯化脂肪酸的血浆水平显著降低。此外，ASX通过减少脂肪细胞的大小对白色脂肪组织表现出显着影响。这些结果表明，ASX改善胰岛素抵抗的机制，包括增加葡萄糖的摄取，并通过调节循环脂质代谢产物和脂联素的水平。(c)2006年爱思唯尔公司All rights reserved.
Glucose and lipid metabolic parameters play crucial roles in metabolic syndrome and its major feature of insulin resistance. This study was designed to investigate whether dietary astaxanthin oil (ASX-O) has potential effects on metabolic syndrome features in an SHR/NDmcr-cp (cp/cp) rat model. Oral administration of ASX (50 mg/kg/day) for 22 weeks induced a significant reduction in arterial blood pressure in SHRcp. It also significantly reduced the fasting blood glucose level, homeostasis index of insulin resistance (HOMA-IR), and improved insulin sensitivity. The results also showed an improved adiponectin level, a significant increase in high-density lipoprotein cholesterol, a significant decrease in plasma levels of triglycerides, and non-esterified fatty acids. Additionally, ASX showed significant effects on the white adipose tissue by decreasing the size of the fat cells. These results suggest that ASX ameliorates insulin resistance by mechanisms involving the increase of glucose uptake, and by modulating the level of circulating lipid metabolites and adiponectin. (c) 2006 Elsevier Inc. All rights reserved.