Relative survival: a useful tool to assess generalisability in longitudinal studies of health in older persons
Relative survival: a useful tool to assess generalisability in longitudinal studies of health in older persons
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DOI：
10.1186/1742-7622-8-3
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发表时间：
2011-02-06
影响因子：
2.3
通讯作者：
Dobson, Annette
中科院分区：
文献类型：
--
作者：
Hockey, Richard;Tooth, Leigh;Dobson, Annette
背景：纵向研究的普遍性受到抽样框架的选择、初始样本的代表性和损耗等问题的威胁。为了确定代表性，通常在人口统计学和健康特征基线上将队列与感兴趣的人群进行比较。这项研究说明了使用相对存活率作为评估老年人队列结果的普遍性的工具，其中死亡是对普遍性的潜在威胁。方法：作者使用了澳大利亚妇女健康纵向研究（ALSWH） 1921-26队列（n = 12,416, 1996年年龄在70-75岁）的数据。生命状态是通过与国家死亡指数的联系来确定的，预期死亡是使用澳大利亚生命表得出的。相对生存是用队列中观察到的生存除以相同年龄和州或地区妇女的预期生存来估计的。结果：总体而言，ALSWH妇女的相对生存率比一般人群高9.5%。在各州和地区内，相对生存优势从6%到23%不等。在回顾的12年中（1996-2008），间隔特异性相对生存率保持相对稳定，表明该队列的生存优势并未随着时间的推移而减弱。结论：本研究表明，相对存活率可以作为一项衡量一般人群健康纵向研究中普遍性的有用指标，特别是当参与者年龄较大时。
Background: Generalisability of longitudinal studies is threatened by issues such as choice of sampling frame, representativeness of the initial sample, and attrition. To determine representativeness, cohorts are often compared with the population of interest at baseline on demographic and health characteristics. This study illustrates the use of relative survival as a tool for assessing generalisability of results from a cohort of older people among whom death is a potential threat to generalisability.Methods: The authors used data from the 1921-26 cohort (n = 12,416, aged 70-75 in 1996) of the Australian Longitudinal Study on Women's Health (ALSWH). Vital status was determined by linkage to the National Death Index, and expected deaths were derived using Australian life tables. Relative survival was estimated using observed survival in the cohort divided by expected survival among women of the same age and State or Territory.Results: Overall, the ALSWH women showed relative survival 9.5% above the general population. Within States and Territories, the relative survival advantage varied from 6% to 23%. The interval-specific relative survival remained relatively constant over the 12 years (1996-2008) under review, indicating that the survival advantage of the cohort has not diminished over time.Conclusion: This study demonstrates that relative survival can be a useful measure of generalisability in a longitudinal study of the health of the general population, particularly when participants are older.