Safety and immunogenicity of gelatin-free varicella vaccine in epidemiological and serological studies in Japan
Safety and immunogenicity of gelatin-free varicella vaccine in epidemiological and serological studies in Japan
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DOI：
10.1016/j.vaccine.2004.08.040
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发表时间：
2005-01-26
期刊：
影响因子：
5.5
通讯作者：
Akiyama, M
中科院分区：
文献类型：
--
作者：
Ozaki, T;Nishimura, N;Akiyama, M
含明胶水痘疫苗（1994-1999年：1,410,000份分发剂量）后，报告了28例严重过敏反应和139例非严重过敏反应，而无明胶疫苗（1999-2000年：1,300,000份分发剂量）后没有严重过敏反应，只有5例非严重反应。来自患有严重反应的儿童的所有 9 份血清均检测出明胶特异性 IgE 呈阳性，而来自非严重反应儿童的 70 份血清中有 55 份呈阳性，其中 1 份呈假阳性。明胶特异性 IgE 抗体滴度与过敏反应严重程度之间不存在相关性。无明胶疫苗组和含明胶疫苗组的免疫后抗水痘抗体滴度相当。新的无明胶水痘疫苗被认为是安全的，与早期的含明胶疫苗具有相似的免疫原性，(C) 2004 Elsevier Ltd. 保留所有权利。
Following gelatin-containing varicella vaccine (1994-1999: 1,410,000 distributed doses), 28 serious anaphylactic reactions and 139 non-serious allergic reactions were reported, with no serious and only five non-serious reactions following gelatin-free vaccine (1999-2000: 1,300,000 distributed doses). All nine sera available from children with serious reactions tested positive for gelatin-specific IgE, whereas 55 of the 70 available from those with non-serious reactions were positive, with one false positive. There was no correlation between gelatin-specific IgE antibody titers and severity of allergic reaction. Post-immunization anti-varicella antibody titers were comparable for both gelatin-free and gelatin-containing vaccine groups. The new gelatin-free varicella vaccine is thought to be safe, with similar immunogenicity to the earlier gelatin-containing vaccine, (C) 2004 Elsevier Ltd. All rights reserved.