Etiology and pathophysiology of osteoarthritis.
Etiology and pathophysiology of osteoarthritis.
复制标题
骨关节炎的病因学和病理生理学。
作者：
B. Mandelbaum;D. Waddell
急性或慢性损伤，包括正常磨损、年龄、肥胖和关节损伤，可能会引发健康软骨中基质合成和基质降解之间的失衡，从而促进软骨丢失并阻止软骨自我修复。健康软骨的结构和其降解的病理生理机制进行了描述，随后描述的内源性和外源性因素被认为是参与骨关节炎的进展过程。引用的研究包括运动医学界的研究。
Acute or chronic insult, including normal wear and tear, age, obesity, and joint injury, may initiate an imbalance between matrix synthesis and matrix degradation in healthy cartilage that promotes chondral loss and prevents cartilage self-repair. The structure of healthy cartilage and the pathophysiological mechanisms of its degradation are described, followed by descriptions of endogenous and exogenous factors believed to be involved in the progressive course of osteoarthritis. Studies cited include research from the community of sports medicine.