Plasma FGF-21 levels in type 2 diabetic patients with ketosis
Plasma FGF-21 levels in type 2 diabetic patients with ketosis
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2 型糖尿病酮症患者血浆 FGF-21 水平
DOI：
10.1016/j.diabres.2008.07.012
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发表时间：
2008-11-01
影响因子：
5.1
通讯作者：
Chen, Wenwen
中科院分区：
文献类型：
--
作者：
Li, Ling;Yang, Gangyi;Chen, Wenwen
FGF-21最近被鉴定为有效的代谢调节剂，但其在人类中的病理生理作用仍然未知。本研究旨在探讨新发2型糖尿病（T2 DM）和糖尿病酮症（T2 DK）患者血浆FGF-21水平是否存在差异。68例T2 DM患者、41例T2 DK受试者和52例性别和年龄匹配的正常对照参与了本研究。用放射免疫法测定血浆FGF-21水平。还分析了血浆FGF-21水平与人体测量和代谢参数之间的关系。T2 DK和T2 DM患者的血浆FGF-21水平高于对照组（分别为4.05 +/- 0.18 μ g/L和2.82 +/- 0.14 μ g/L vs. 2.28 +/- 0.16 μ g/L，P < 0.01和P < 0.05）。发现空腹血浆FGF-21与SBP、DBP、FBG、2 hPBG、HbA（1）c、HDL-C和FFA呈显著正相关，但与空腹血浆胰岛素、2 hIns和HOMA呈负相关（15）。多元回归分析显示，DBP、WHR、2 hIns、2 hPBG和FFA是影响血浆FGF-21水平的独立因素。FGF-21浓度的增加与T2 DM和T2 DK独立且显著相关。目前的研究表明，FGF-21可能在T2 DM和T2 DK的发病机制中发挥作用。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
FGF-21 has been recently characterized as a potent metabolic regulator, but its pathophysiologic role in human remains unknown. In this study we investigate whether plasma FGF-21 level is different in patients with new-onset type 2 diabetes mellitus (T2DM) and diabetic ketosis (T2DK). Sixty-eight patients with T2DM, 41 subjects with T2DK, and 52 sex- and age-matched normal controls participated in the study. Plasma FGF-21 levels were measured with a radioimmunoassay. The relationship between plasma FGF-21 levels and anthropometric and metabolic parameters was also analyzed. Plasma FGF-21 levels were higher in patients with T2DK and T2DM than in controls (4.05 +/- 0.18 mu g/L and 2.82 +/- 0.14 mu g/L vs. 2.28 +/- 0.16 mu g/L, P < 0.01 and P < 0.05, respectively). Fasting plasma FGF-21 was found to correlate positively and significantly with SBP, DBP, FBG, 2hPBG, HbA(1)c, HDL-C and FFA, but negatively with fasting plasma insulin, 2hIns and HOMA(15). Multiple regression analysis showed that DBP, WHR, 2hIns, 2hPBG and FFA were independent to the factors influencing plasma FGF-21 levels. increasing concentrations of FGF-21 were independently and significantly associated with T2DM and T2DK. The present work suggests that FGF-21 may play a role in the pathogenesis of T2DM and T2DK. (C) 2008 Elsevier Ireland Ltd. All rights reserved.