The retroviral RNA dimer linkage: different structures may reflect different roles.
The retroviral RNA dimer linkage: different structures may reflect different roles.
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DOI：
10.1186/1742-4690-1-22
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发表时间：
2004-08-18
期刊：
影响因子：
3.3
通讯作者：
Greatorex J
中科院分区：
文献类型：
--
作者：
Greatorex J
逆转录病毒在具有二聚体基因组的病毒家族中是独特的。连接两个RNA分子的RNA序列和结构各不相同，这些差异为该特征在病毒生命周期中的作用提供了线索。本审查借鉴了不同的逆转录病毒家族的例子。二级和三级结构的差异和相似之处进行了讨论。被认为是在相关病毒的二聚体连接的不同角色的含义。
Retroviruses are unique among virus families in having dimeric genomes. The RNA sequences and structures that link the two RNA molecules vary, and these differences provide clues as to the role of this feature in the viral lifecycles. This review draws upon examples from different retroviral families. Differences and similarities in both secondary and tertiary structure are discussed. The implication of varying roles for the dimer linkage in related viruses is considered.