CD147 Is Essential for the Development of Psoriasis via the Induction of Th17 Cell Differentiation.
CD147 Is Essential for the Development of Psoriasis via the Induction of Th17 Cell Differentiation.
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DOI：
10.3390/ijms23010177
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发表时间：
2021-12-24
影响因子：
5.6
通讯作者：
Kanekura T
中科院分区：
文献类型：
--
作者：
Okubo A;Uchida Y;Higashi Y;Sato T;Ogawa Y;Ryuge A;Kadomatsu K;Kanekura T
Th 17细胞在银屑病发病中起重要作用。幼稚CD 4 + T细胞分化为Th 17细胞依赖于糖酵解作为能量来源。CD 147/basigin是一种属于免疫球蛋白超家族的完整跨膜蛋白，与癌细胞和T细胞中的单羧酸转运蛋白（MCT）-1和-4相关，调节糖酵解。我们研究了CD 147/basigin是否参与人类和银屑病模型小鼠银屑病的发病机制。银屑病患者血清CD 147水平升高，真皮CD 4 + RORγt+ T细胞中CD 147和MCT-1表达升高。在体外，幼稚的CD 4 + T细胞分化为Th 17细胞的潜力在CD 147 −/− T细胞中被废除。咪喹莫特（IMQ）诱导的银屑病皮炎在CD 147 −/−小鼠和骨髓谱系造血细胞中缺乏CD 147的骨髓嵌合小鼠中明显较轻。这些发现表明，CD 147通过诱导Th 17细胞分化对银屑病的发展至关重要。
Th17 cells play an important role in psoriasis. The differentiation of naïve CD4+ T cells into Th17 cells depends on glycolysis as the energy source. CD147/basigin, an integral transmembrane protein belonging to the immunoglobulin superfamily, regulates glycolysis in association with monocarboxylate transporters (MCTs)-1 and -4 in cancer cells and T cells. We examined whether CD147/basigin is involved in the pathogenesis of psoriasis in humans and psoriasis-model mice. The serum level of CD147 was increased in patients with psoriasis, and the expression of CD147 and MCT-1 was elevated in their dermal CD4+ RORγt+ T cells. In vitro, the potential of naïve CD4+ T cells to differentiate into Th17 cells was abrogated in CD147−/− T cells. Imiquimod (IMQ)-induced psoriatic dermatitis was significantly milder in CD147−/− mice and bone marrow chimeric mice lacking CD147 in the hematopoietic cells of myeloid lineage. These findings demonstrate that CD147 is essential for the development of psoriasis via the induction of Th17 cell differentiation.
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影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
靶向 CD147 的 siRNA 通过下调糖酵解抑制人恶性黑色素瘤细胞的增殖、侵袭和 VEGF 产生
影响因子：
9.7
作者：
Su, Juan;Chen, Xiang;Kanekura, Takuro
通讯作者：
Kanekura, Takuro
影响因子：
6.5
作者：
Martin, David A.;Towne, Jennifer E.;Kricorian, Gregory;Klekotka, Paul;Gudjonsson, Johann E.;Krueger, James G.;Russell, Chris B.
通讯作者：
Russell, Chris B.
DOI：
10.1073/pnas.1106123108
发表时间：
2011-10-04
影响因子：
11.1
作者：
Le Floch, Renaud;Chiche, Johanna;Pouyssegur, Jacques
通讯作者：
Pouyssegur, Jacques
影响因子：
11.2
作者：
Gallagher, Shannon M.;Castorino, John J.;Philp, Nancy J.
通讯作者：
Philp, Nancy J.