In vivo treatment with the NF-κB inhibitor ursodeoxycholic acid (UDCA) improves tension development in the isolated mdx costal diaphragm.
In vivo treatment with the NF-κB inhibitor ursodeoxycholic acid (UDCA) improves tension development in the isolated mdx costal diaphragm.
复制标题
使用 NF-κB 抑制剂熊去氧胆酸 (UDCA) 进行体内治疗可改善离体 mdx 肋膈肌的张力发展。
DOI：
10.1002/mus.24755
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发表时间：
2016
期刊：
影响因子：
3.4
通讯作者：
Nielsen,Cory
中科院分区：
文献类型：
--
作者：
Carlson,CGeorge;Potter,Ross;Yu,Vivien;Luo,Kevin;Lavin,Jesse;Nielsen,Cory
简介：先前的实验表明，熊去氧胆酸（UDCA）体内给药可抑制核NF-κB活化，对营养不良（mdx）肌肉的结构和功能具有有益作用。我们研究了UDCA对营养不良muscle.Methods中张力发展的影响：在新鲜分离自溶剂和UDCA处理的mdx小鼠的肋膈中检查等长张力发展。通过直接比较这些测量值与从年龄匹配的nondystrophic mice.Results获得的恢复分数百分比：与年龄匹配的nondystrophic mice相比，溶剂处理的mdx mice表现出显著降低的最佳肌肉长度（lo）和特定的抽搐和强直张力。UDCA处理的制剂表现出显著改善张力发展，恢复评分为33%。结论：由于UDCA用于治疗某些临床疾病，因此这些结果为使用该药物和相关药物治疗杜氏肌营养不良症和相关肌营养不良症的人体临床试验提供了依据。Muscle Nerve 53：431-437，2016
Introduction: Previous experiments have indicated thatin vivoadministration of ursodeoxycholic acid (UDCA) inhibits nuclear NF‐κB activation and has beneficial effects on the structure and function of dystrophic (mdx) muscle. We examined the effect of UDCA on tension development in dystrophic muscle.Methods: Isometric tension development was examined in costal diaphragms that were freshly isolated from vehicle and UDCA treatedmdxmice. Percent recovery scores were obtained by directly comparing these measurements to those obtained from age‐matched nondystrophic mice.Results: Vehicle treatedmdxmice exhibited significantly reduced optimal muscle lengths (lo) and specific twitch and tetanic tensions compared with age‐matched nondystrophic mice. UDCA treated preparations exhibited significantly improved tension development with a 33% recovery score.Conclusions: Because UDCA is used in treating certain clinical disorders, these results provide a rationale for human clinical trials using this and related drugs for treatment of Duchenne and related muscular dystrophies.Muscle Nerve53: 431–437, 2016