Oxidative Stress, Sarcopenia, Antioxidant Strategies and Exercise: Molecular Aspects
Oxidative Stress, Sarcopenia, Antioxidant Strategies and Exercise: Molecular Aspects
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DOI：
10.2174/1381612822666160219120531
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发表时间：
2016-01-01
影响因子：
3.1
通讯作者：
Lemoine-Morel, Sophie
中科院分区：
文献类型：
--
作者：
Brioche, Thomas;Lemoine-Morel, Sophie
肌肉减少症目前可以定义为一种老年综合征，最初的特征是肌肉质量减少，随后会恶化，导致力量和身体表现恶化。负蛋白质周转、受损的线粒体动力学和功能、降低的肌肉再生能力以及细胞凋亡的加剧通常被认为是涉及导致肌肉减少症的肌肉萎缩的细胞机制。在这篇综述中，我们首先提出，在衰老过程中观察到的肌肉过量产生的活性氧和氮（RONS）和氧化应激与肌肉减少症，然后讨论RONS是如何参与氧化还原敏感的信号通路，导致肌肉减少症。确定具有成本效益的干预措施，以维持老年人的肌肉质量和身体功能，是最重要的公共卫生挑战之一。在这里，我们也讨论了不同类型的抗氧化剂策略对肌减少症的有效性。由于运动是预防和逆转肌肉减少症的最佳策略，我们还强调运动可以作为抗氧化剂。
Sarcopenia could be currently defined as a geriatric syndrome initially characterized by a decrease in muscle mass that will get worse causing deterioration in strength and physical performance. A negative protein turnover, impaired mitochondrial dynamics and functions, a decreased muscle regeneration capacity, as well as an exacerbation of apoptosis are usually considered to be cellular mechanisms involved in muscle atrophy leading to sarcopenia. In this review, we first present that muscle overproduction of reactive oxygen and nitrogen species (RONS) and oxidative stress observed during aging are associated with sarcopenia, and then discuss how RONS are involved in redox-sensitive signaling pathways leading to sarcopenia. The identification of cost-effectiveness interventions to maintain muscle mass and physical functions in the elderly is one of the most important public health challenges. Here, we also discuss about the efficiency of different kind of antioxidant strategies against sarcopenia. Since exercise is the best strategy to prevent and reverse sarcopenia, we also highlight that exercise acts as an antioxidant.