The NF-κB Pathway and Cancer Stem Cells.
The NF-κB Pathway and Cancer Stem Cells.
复制标题
DOI：
10.3390/cells5020016
复制
发表时间：
2016-04-06
期刊：
影响因子：
6
通讯作者：
Baldwin AS
中科院分区：
文献类型：
--
作者：
Rinkenbaugh AL;Baldwin AS
NF-κB转录因子通路是炎症和免疫应答的重要调节因子。此外，在许多类型的癌症中已经鉴定出异常的NF-κB信号传导。在关键致癌途径如RAS、BCR-ABL和Her 2的下游，NF-κB调节靶基因的转录，这些靶基因促进细胞存活和增殖、抑制凋亡并介导侵袭和转移。癌症干细胞模型假定肿瘤细胞（癌症干细胞）的子集驱动肿瘤起始，表现出对治疗的抗性，并促进复发和转移。本文综述了NF-κB信号在肿瘤干细胞生物学中的作用。
The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell survival and proliferation, inhibit apoptosis, and mediate invasion and metastasis. The cancer stem cell model posits that a subset of tumor cells (cancer stem cells) drive tumor initiation, exhibit resistance to treatment, and promote recurrence and metastasis. This review examines the evidence for a role for NF-κB signaling in cancer stem cell biology.