Asymmetric Dearomative Halogenation of beta-Naphthols: The Axial Chirality Transfer Reaction
Asymmetric Dearomative Halogenation of beta-Naphthols: The Axial Chirality Transfer Reaction
复制标题
β-萘酚的不对称脱芳卤化：轴向手性转移反应
DOI：
10.1002/adsc.201700745
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发表时间：
2018
影响因子：
5.4
通讯作者：
Wang Rui
中科院分区：
文献类型：
--
作者：
Wang Pengxin;Wang Jie;Wang Linqing;Li Dan;Wang Kezhou;Liu Yuyang;Zhu Haiyong;Liu Xihong;Yang Dongxu;Wang Rui
Axial naphthols are applied in asymmetric halogenative dearomatization reactions under simple and mild conditions in the work presented herein. The axial‐to‐central chirality conversion is efficiently accomplished, and the desired halogenated dearomatization products are obtained in high yields and enantioselectivities. By using commercially available halogenation reagents, the asymmetric fluorinative, chlorinative and brominative dearomatization reactions of axial naphthols derived from BINOLs are achieved. (BINOL=1,1′‐Bi‐2‐naphthol)
