The effect of a novel smoking system - Accord on ongoing smoking and toxin exposure
The effect of a novel smoking system - Accord on ongoing smoking and toxin exposure
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DOI：
10.1080/14622200412331296011
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发表时间：
2004-12-01
影响因子：
4.7
通讯作者：
Keely, JP
中科院分区：
文献类型：
--
作者：
Hughes, JR;Keely, JP
多种潜在减少暴露产品（PREP）正在被引入市场，但人们对它们的使用方式以及它们可能对公共健康产生的影响知之甚少。为了确定这样一项 PREP-Accord-对持续吸烟和毒素暴露的影响，11 名淡味香烟吸烟者被要求增加使用 Accord 的量（每天 5、10 和 15 支），同时可以选择使用传统香烟。 Accord 以剂量依赖性方式抑制每天持续吸烟和一氧化碳 (CO)，但不抑制可替宁。每天吸 15 支 Accord 可将传统香烟的吸食量减少 32%（每天 -8.6 支），一氧化碳含量减少 27%（-5.9 ppm）。然而，Accord 并没有成为香烟的完美（即一对一）替代品，因为每天尼古丁产品（Accord 加上常用品牌）的总数增加了 24%。参与者认为 Accord 比传统香烟更安全，但认为 Accord 在抑制香烟渴望方面无效。这些发现表明，使用 Accord 可以显着减少吸烟量和二氧化碳暴露量。这些减少是否会转化为健康益处或持续超过两周尚不清楚。由于大多数 PREP 可能会与传统香烟一起使用，因此它们对健康的净影响不仅取决于其毒理学特征，还取决于其对持续吸烟的影响。
Multiple potentially reduced exposure products (PREPs) are being introduced to the market, yet little is known about how they will be used and what their public health impact might be. To determine the impact of one such PREP-Accord-on ongoing smoking and toxin exposure, 11 smokers of light cigarettes were required to use increasing amounts of Accord (5, 10, and 15 per day) with the option of using their traditional cigarettes. Accord suppressed ongoing cigarettes per day and carbon monoxide (CO), but not cotinine, in a dose-dependent manner. Smoking 15 Accord per day decreased the number of traditional cigarettes smoked by 32% (-8.6 cigarettes per day) and CO levels by 27% (-5.9 ppm). However, Accord did not function as a perfect (i.e., one to one.) substitute for cigarettes because the total number of nicotine products (Accord plus usual brand) per day increased by 24%. Participants believed that Accord was safer than traditional cigarettes but rated Accord as ineffective at suppressing cravings for cigarettes. These findings suggest that use of Accord results in significant decreases in cigarettes smoked and CO exposure. Whether these reductions will translate into health benefits or endure beyond 2 weeks is unknown. Because most PREPs will probably be used along with traditional cigarettes, their net health impact is a function of not only their toxicological profile but also their effect on ongoing smoking.