Poor maternal care and high maternal body mass index in pregnancy as a risk factor for schizophrenia in offspring
Poor maternal care and high maternal body mass index in pregnancy as a risk factor for schizophrenia in offspring
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DOI：
10.1111/j.1600-0447.2004.00380.x
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发表时间：
2004-10-01
影响因子：
6.7
通讯作者：
Takei, N
中科院分区：
文献类型：
--
作者：
Kawai, M;Minabe, Y;Takei, N
目的：我们调查了母亲的产前因素是否会增加后代患精神分裂症的风险，并检查了这些因素与产科并发症（OC）史之间的任何关系。方法：使用52例精神分裂症患者和284例健康人的母婴健康手册，我们评估了产前检查频率和母亲在怀孕早期和晚期的体重指数（BMI）的风险增加效应。结果：在logistic回归分析中，产前检查次数与疾病风险之间存在显著相关性;增加一个单位的访问对应于风险降低12%。我们还发现，怀孕早期BMI增加一个单位，风险增加24%，怀孕后期增加19%。这些产前因素被发现，在一定程度上，以过量的OC在个人与schizophrenia.Conclusion：产妇护理不佳，特别是在怀孕早期的孕产妇BMI相对较高，可能会导致精神分裂症的后代的易感性。
Objective: We investigated whether antenatal factors in mothers would increase the risk of schizophrenia in the offspring, and also examined any relationship between these factors and histories of obstetric complications (OCs).Method: Using the Mother and Child Health Handbooks of 52 patients with schizophrenia and 284 healthy subjects, we evaluated the risk-increasing effects of the frequency of antenatal care visits and mothers' body mass index (BMI) at both early and late pregnancy.Results: In logistic regression analysis, there was a significant association between the number of antenatal care visits and the risk of the disorder; an increase in a unit of visits corresponds to a reduction of the risk by 12%. We also found a 24% increase in the risk with a one-unit increase of BMI at the early pregnancy, and a 19% increase at the late pregnancy. These antenatal factors were found to contribute, in part, to an excess of OCs in individuals with schizophrenia.Conclusion: Poor maternal care during pregnancy and comparatively high maternal BMI especially at early pregnancy may cause a predisposition to schizophrenia in the offspring.