Risk factors for acute pain and its persistence following breast cancer surgery
Risk factors for acute pain and its persistence following breast cancer surgery
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DOI：
10.1016/j.pain.2005.09.008
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发表时间：
2005-12-15
期刊：
影响因子：
7.4
通讯作者：
Dworkin, RH
中科院分区：
文献类型：
--
作者：
Katz, J;Poleshuck, EL;Dworkin, RH
虽然更严重的急性术后疼痛会增加乳腺癌手术后慢性疼痛的风险，但很少有研究检查发生更严重急性疼痛的患者的特征。为了确定乳腺癌手术后一个月急性疼痛及其持续性的危险因素，对114名计划接受乳腺癌手术的女性样本进行了术前人口统计学、临床和情绪功能变量的评估，这些变量被假设为与急性疼痛严重程度相关。在术后2、10和30天的随访中评估有临床意义的术后疼痛。在单变量分析中，年轻、未婚、有更多侵入性手术和术前情绪困扰的女性发生有临床意义的急性疼痛的风险增加。在多元逻辑回归分析中，术前焦虑是唯一一个独立预测术后2天有临床意义的急性疼痛的变量，而年轻、未婚和术前焦虑分别独立预测术后2 - 30天持续有临床意义的急性疼痛。这些结果增加了对神经生物学机制和心理社会过程的理解，这些机制和心理社会过程有助于乳腺癌手术后急性疼痛的发展，并对预防疼痛的干预措施的发展产生影响。Elsevier B. V.出版，保留所有权利。
Although more severe acute postoperative pain increases the risk of chronic pain following breast cancer surgery, few studies have examined the characteristics of patients who develop greater acute pain. To identify risk factors for acute pain and its persistence one month following breast cancer surgery, a sample of 114 women scheduled for breast cancer surgery was assessed preoperatively for demographic, clinical, and emotional functioning variables that were hypothesized to be associated with acute pain severity. Clinically meaningful postoperative pain was assessed at follow-up interviews 2, 10, and 30 days after surgery. In univariate analyses, the risk of clinically meaningful acute pain was increased among women who were younger, unmarried, had more invasive surgeries, and had greater preoperative emotional distress. In multiple logistic regression analyses, greater preoperative anxiety was the only variable that made an independent contribution to predicting clinically meaningful acute pain at 2 days after surgery whereas younger age, being unmarried, and preoperative anxiety each made an independent contribution to predicting clinically meaningful acute pain that persisted from 2 to 30 days after surgery. These results increase understanding of neurobiologic mechanisms and psychosocial processes that contribute to the development of acute pain following breast cancer surgery and have implications for the development of interventions to prevent it. (c) 2005 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.