LONG-TERM SEQUELAE OF TREATMENT FOR TESTICULAR GERM-CELL TUMORS
LONG-TERM SEQUELAE OF TREATMENT FOR TESTICULAR GERM-CELL TUMORS
复制标题
DOI：
10.1038/bjc.1990.350
复制
发表时间：
1990-10-01
影响因子：
8.8
通讯作者：
KAYE, SB
中科院分区：
文献类型：
--
作者：
BISSETT, D;KUNKELER, L;KAYE, SB
74例以前在我科治疗的睾丸生殖细胞肿瘤患者进行了一系列测试，以确定长期治疗并发症的频率。作为治疗的一部分，所有人都接受了基于顺铂的化疗。整个组的肾功能显著恶化。18例（24%）治疗后仰卧位血压高于收缩压140 mmHg或舒张压90 mmHg，但高血压与肾损害无关。化疗后Raynaud现象（26/74）和持续性感觉神经病变（23/74）较常见。虽然34%的患者睾酮水平低于正常范围，但只有6例患者游离睾酮指数较低，其中1例睾丸仍在原位; 18例患者在化疗后有了孩子。大约一半的患者完成了性心理问卷调查，其中约30%的人承认性问题，他们归因于他们的治疗。睾丸恶性肿瘤顺铂化疗的长期后遗症是频繁和持久的，这些患者的随访应包括前瞻性测量血压的变化。
Seventy-four patients previously treated in our department for germ cell tumour of the testis underwent a series of tests to determine the frequency of long-term therapeutic complications. All had received cisplatin-based chemotherapy as part of their treatment. There was a significant deterioration in renal function throughout the group. Eighteen (24%) had supine blood pressure greater than systolic 140 mmHg or diastolic 90 mmHg after treatment but hypertension did not correlate with renal impairment. Raynaud''s phenomenon was common after chemotherapy (26/74) as was persistent sensory neuropathy (23/74). Although 34% had testosterone levels below the normal range, only six patients had a low free testosterone index with one testis still in situ; 18 patients have fathered children after chemotherapy. Approximately half of the patients completed a psychosexual questionnaire and some 30% of them admitted to sexual problems which they attributed to their treatment. Long-term sequelae of cisplatin-based chemotherapy for testicular malignancy are frequent and persistent, and follow-up of these patients should include prospective measurement of changes in blood pressure.