Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems
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DOI：
10.1073/pnas.96.2.748
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发表时间：
1999-01-19
影响因子：
11.1
通讯作者：
Nakazato, M
中科院分区：
文献类型：
--
作者：
Date, Y;Ueta, Y;Nakazato, M
我们确定了食欲素-A和食欲素-B的免疫组织化学分布，下丘脑肽，在摄食行为和能量稳态的调节功能。Orexin-A和-B神经元仅限于下丘脑外侧和后部，而Orexin-A和-B神经纤维广泛投射到嗅球、大脑皮质、丘脑、下丘脑和脑干。在丘脑室旁核、中央灰质、中缝核和蓝斑中存在密集的含Orexin的纤维，在嗅球中发现中等数量的这些纤维，岛叶、边缘下和边缘前皮质、杏仁核、视交叉上核的腹侧和背外侧部分、室旁核（除外侧大细胞区外）、弓状核、乳头体上核、孤束核和迷走神经背侧运动核。室旁核外侧大细胞区也有少量。侧脑室注射orexins诱导c-fos在丘脑室旁核，蓝斑，弓状核，中央灰质，中缝核，孤束核，迷走神经背侧运动核，视交叉上核，视上核和室旁核的表达，除了外侧大细胞分裂。食欲素独特的神经元分布和它们的神经回路功能激活表明肽在自主神经和神经内分泌控制中的特定复杂作用。
We determined the immunohistochemical distributions of orexin-A and orexin-B, hypothalamic peptides that function in the regulation of feeding behavior and energy homeostasis. Orexin-A and -B neurons were restricted to the lateral and posterior hypothalamus, whereas both orexin-A and -B nerve fibers projected widely into the olfactory bulb, cerebral cortex, thalamus, hypothalamus, and brainstem, Dense populations of orexin containing fibers were present in the paraventricular thalamic nucleus, central gray, raphe nuclei, and locus coeruleus, Moderate numbers of these fibers were found in the olfactory bulb, insular, infralimbic and prelimbic cortex, amygdala, ventral, and dorsolateral parts of the suprachiasmatic nucleus, paraventricular nucleus except the lateral magnocellular division, arcuate nucleus, supramammillary nucleus, nucleus of the solitary tract, and dorsal motor nucleus of the vagus, Small numbers of orexin fibers were present in the perirhinal, motor and sensory cortex, hippocampus, and supraoptic nucleus, and a very small number in the lateral magnocellular division of the paraventricular nucleus. Intracerebroventricular injections of orexins induced c-fos expression in the paraventricular thalamic nucleus, locus coeruleus, arcuate nucleus, central gray, raphe nuclei, nucleus of the solitary tract, dorsal motor nucleus of the vagus, suprachiasmatic nucleus, supraoptic nucleus, and paraventricular nucleus except the lateral magnocellular division. The unique neuronal distribution of orexins and their functional activation of neural circuits suggest specific complex roles of the peptides in autonomic and neuroendocrine control.