Synthesis of a triphenylphosphine reagent on non-cross-linked polystyrene support: Application to the Staudinger/Aza-Wittig reaction
Synthesis of a triphenylphosphine reagent on non-cross-linked polystyrene support: Application to the Staudinger/Aza-Wittig reaction
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DOI：
10.1021/ol006432w
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发表时间：
2000-11-30
期刊：
影响因子：
5.2
通讯作者：
Janes, MK
中科院分区：
文献类型：
--
作者：
Charette, AB;Boezio, AA;Janes, MK
合成了一种连接到线性聚苯乙烯上的新三苯基膦试剂。这种膦键合聚合物的反应性上级于与交联聚苯乙烯键合的膦。该聚合物与叠氮化物反应非常迅速，生成亚氨基膦，然后亚氨基膦可以与醛反应，以良好的产率和高纯度生成亚胺。
[GRAPHICS]A new triphenylphosphine reagent linked to a linear polystyrene was synthesized. The reactivity of this phosphine-bound polymer is superior to that of the phosphine bound to cross-linked polystyrene. The polymer reacted very rapidly with azides to generate iminophosphoranes which could then react with aldehydes to generate imines in good yields and high purities.