Parasitic Nematode Immunomodulatory Strategies: Recent Advances and Perspectives.
Parasitic Nematode Immunomodulatory Strategies: Recent Advances and Perspectives.
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DOI：
10.3390/pathogens5030058
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发表时间：
2016-09-14
期刊：
影响因子：
--
通讯作者：
Eleftherianos I
中科院分区：
文献类型：
--
作者：
Cooper D;Eleftherianos I
所描述的线虫门物种中有一半以上被认为是寄生性的，这使它们成为最成功的寄生虫类群之一。线虫能够栖息在多种生态位中。大量脊椎动物、昆虫和植物都被确定为线虫寄生的潜在宿主。为了成功入侵这些宿主，寄生线虫必须能够保护自己免受宿主免疫系统的效率和效力的影响。先天免疫包括宿主免疫反应的第一波，在脊椎动物中，它导致适应性免疫反应的诱导。线虫已经进化出优雅的策略，使它们能够逃避、抑制或调节宿主的免疫反应，以便在宿主体内持续存在和传播。线虫免疫调节涉及分泌能够抑制宿主免疫反应各个方面的分子，以促进线虫入侵。可以在感染昆虫、植物和哺乳动物的寄生线虫中鉴定出免疫调节机制，并且寄生虫改变宿主免疫反应的具体策略差异很大。线虫衍生的免疫调节作用也被证明会对宿主所患的一些并发疾病的结果产生负面或正面的影响。了解线虫的免疫调节作用将有可能揭示新的靶标，从而开发出控制破坏性线虫寄生虫的有效方法。
More than half of the described species of the phylum Nematoda are considered parasitic, making them one of the most successful groups of parasites. Nematodes are capable of inhabiting a wide variety of niches. A vast array of vertebrate animals, insects, and plants are all identified as potential hosts for nematode parasitization. To invade these hosts successfully, parasitic nematodes must be able to protect themselves from the efficiency and potency of the host immune system. Innate immunity comprises the first wave of the host immune response, and in vertebrate animals it leads to the induction of the adaptive immune response. Nematodes have evolved elegant strategies that allow them to evade, suppress, or modulate host immune responses in order to persist and spread in the host. Nematode immunomodulation involves the secretion of molecules that are capable of suppressing various aspects of the host immune response in order to promote nematode invasion. Immunomodulatory mechanisms can be identified in parasitic nematodes infecting insects, plants, and mammals and vary greatly in the specific tactics by which the parasites modify the host immune response. Nematode-derived immunomodulatory effects have also been shown to affect, negatively or positively, the outcome of some concurrent diseases suffered by the host. Understanding nematode immunomodulatory actions will potentially reveal novel targets that will in turn lead to the development of effective means for the control of destructive nematode parasites.
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影响因子：
7.3
作者：
Al-Riyami L;Pineda MA;Rzepecka J;Huggan JK;Khalaf AI;Suckling CJ;Scott FJ;Rodgers DT;Harnett MM;Harnett W
通讯作者：
Harnett W
DOI：
10.1111/j.1440-1681.2006.04400.x
发表时间：
2006-05-01
影响因子：
2.9
作者：
Harnett, W;Harnett, MM
通讯作者：
Harnett, MM
影响因子：
1.5
作者：
Del Valle, A;Jones, BF;Cappello, M
通讯作者：
Cappello, M
影响因子：
4.4
作者：
Goodridge, HS;Marshall, FA;Harnett, MM
通讯作者：
Harnett, MM
影响因子：
9.6
作者：
de Silva, NR;Brooker, S;Savioli, L
通讯作者：
Savioli, L