Molecular Hydrogen as a Neuroprotective Agent.
Molecular Hydrogen as a Neuroprotective Agent.
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DOI：
10.2174/1570159x14666160607205417
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发表时间：
2017
影响因子：
5.3
通讯作者：
Ohsawa I
中科院分区：
文献类型：
--
作者：
Iketani M;Ohsawa I
氧化应激和神经炎症导致许多神经系统疾病。最近，据报道，分子氢（H2）作为抗氧化剂和抗炎剂的功能。在动物模型和人体临床研究中，H2给药途径大致分为三种类型，吸入H2气体、饮用溶解有H2的水和注射溶解有H2的盐水。这篇综述讨论了一些显着的进展，已在研究中取得的H2用于神经系统疾病，如脑血管疾病，神经退行性疾病，新生儿脑疾病。虽然目前大多数神经系统疾病是无法治愈的，但这些研究表明H2给药在预防、治疗和缓解这些疾病方面具有临床潜力。还将讨论H2的几种潜在效应物，包括负责防止氧化应激和炎症的细胞信号分子和激素。然而，需要进一步研究以确定H2的直接靶分子。
Oxidative stress and neuroinflammation cause many neurological disorders. Recently, it has been reported that molecular hydrogen (H2) functions as an antioxidant and anti-inflammatory agent. The routes of H2 administration in animal model and human clinical studies are roughly classified into three types, inhalation of H2 gas, drinking H2-dissolved water, and injection of H2-dissolved saline. This review discusses some of the remarkable progress that has been made in the research of H2 use for neurological disorders, such as cerebrovascular diseases, neurodegenerative disorders, and neonatal brain disorders. Although most neurological disorders are currently incurable, these studies suggest the clinical potential of H2 administration for their prevention, treatment, and mitigation. Several of the potential effectors of H2 will also be discussed, including cell signaling molecules and hormones that are responsible for preventing oxidative stress and inflammation. Nevertheless, further investigation will be required to determine the direct target molecule of H2.