Optimal experimental design for filter exchange imaging: Apparent exchange rate measurements in the healthy brain and in intracranial tumors.
Optimal experimental design for filter exchange imaging: Apparent exchange rate measurements in the healthy brain and in intracranial tumors.
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DOI：
10.1002/mrm.26195
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发表时间：
2017-03
影响因子：
3.3
通讯作者：
Nilsson M
中科院分区：
文献类型：
--
作者：
Lampinen B;Szczepankiewicz F;van Westen D;Englund E;C Sundgren P;Lätt J;Ståhlberg F;Nilsson M
滤过器交换成像(FEXI)对扩散水交换速率敏感，而扩散水交换速率依赖于细胞膜的通透性。其目的是优化和分析FEXI推断两个群体之间大脑表观交换率(AXR)差异的能力。对FEXI协议进行了优化，使AXR中的测量差异最小。通过对18名健康志愿者的6个脑区进行重测，研究了AXR的变异。对6例脑膜瘤和5例星形细胞瘤患者进行了术前FEXI检查和术后显微照片检查。协议优化使AXR的变异系数降低了约40%。重测的AXR值在正常脑区表现不一，从0.3 ± 0.2 S−1到1.8 ± 0.3 S−1额叶白质。经统计功率分析，除1个脑区外，每组5~10名受试者可推断出S−-1的AXR差异为0.3~0.5。脑膜瘤和星形细胞瘤的AXR值分别为0.6 ± 0.1 S−1和1.0 ± 0.3 S−1。使用优化的协议，FEXI能够在小群体规模的情况下推断两个群体之间的AXR的相关差异。Magn Reson Med 77：1104-1114,2017。《医学中的磁共振》作者由威利期刊公司代表国际医学磁共振学会出版。本文是一篇开放获取的文章，遵循知识共享署名-非商业-NoDerivs许可证的条款，该许可证允许在任何媒体上使用和分发，只要正确引用原始作品，使用是非商业性的，并且没有进行任何修改或改编。
Filter exchange imaging (FEXI) is sensitive to the rate of diffusional water exchange, which depends, eg, on the cell membrane permeability. The aim was to optimize and analyze the ability of FEXI to infer differences in the apparent exchange rate (AXR) in the brain between two populations. A FEXI protocol was optimized for minimal measurement variance in the AXR. The AXR variance was investigated by test‐retest acquisitions in six brain regions in 18 healthy volunteers. Preoperative FEXI data and postoperative microphotos were obtained in six meningiomas and five astrocytomas. Protocol optimization reduced the coefficient of variation of AXR by approximately 40%. Test‐retest AXR values were heterogeneous across normal brain regions, from 0.3 ± 0.2 s−1 in the corpus callosum to 1.8 ± 0.3 s−1 in the frontal white matter. According to analysis of statistical power, in all brain regions except one, group differences of 0.3–0.5 s−1 in the AXR can be inferred using 5 to 10 subjects per group. An AXR difference of this magnitude was observed between meningiomas (0.6 ± 0.1 s−1) and astrocytomas (1.0 ± 0.3 s−1). With the optimized protocol, FEXI has the ability to infer relevant differences in the AXR between two populations for small group sizes. Magn Reson Med 77:1104–1114, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.