Hemispheric lateralization of number comparison
Hemispheric lateralization of number comparison
复制标题
DOI：
10.1016/j.cogbrainres.2005.06.002
复制
发表时间：
2005-09-01
期刊：
影响因子：
--
通讯作者：
Olivier, E
中科院分区：
文献类型：
--
作者：
Andres, M;Seron, X;Olivier, E
为了阐明右侧和左侧后顶叶皮层（PPC）对数字比较的各自贡献，使用经颅磁刺激（TMS）来破坏受试者的PPC处理，以确定数字是小于还是大于5。单脉冲TMS应用于PPC，无论是单侧或双侧，150，200，或250英寸后，数字显示。假TMS用作对照条件，以考虑TMS对反应时间（RT）的非特异性影响。本研究的主要发现是，当比较接近5的数字时，在单独破坏左侧PPC或同时破坏两个PPC后，RT显著增加。仅破坏一个PPC未改变远离5的数字的比较，但在双侧PPC刺激后发现RT增加。观察到这些破坏性的影响，无论TMS延迟。我们的结论是，编码精确的数值需要完整的左PPC，建议的赤字在歧视接近数字随之而来的中断。相比之下，近似比较可以由左PPC或右PPC处理，因为需要同时进行双侧TMS来改变远离5的数字的比较。(c)2005 Elsevier B.V保留所有权利。
In order to clarify the respective contribution of the right and left posterior parietal cortex (PPC) to number comparison, transcranial magnetic stimulation (TMS) was used to disrupt PPC processing in subjects instructed to determine whether a digit was smaller or larger than 5. Single pulse TMS was applied over the PPC, either unilaterally or bilaterally, 150, 200, or 250 ins after digit presentation. Sham TMS was used as a control condition to take into account the unspecific effects of TMS on reaction time (RT). The main finding of the present study is a significant increase in RTs when comparing digits close to 5 following a disruption either of the left PPC alone or of both PPC simultaneously. The comparison of digits far from 5 was unaltered by disrupting only one PPC but RTs were found increased after bilateral PPC stimulation. These disruptive effects were observed irrespective of the TMS delay. We concluded that coding precise numerical values requires the integrity of the left PPC, as suggested by the deficit in discriminating close digits consequent to its disruption. In contrast, approximate comparisons can be processed either by the left or right PPC, since simultaneous bilateral TMS was needed to alter the comparison of digits far from 5. (c) 2005 Elsevier B.V All rights reserved.