RASSF6; the Putative Tumor Suppressor of the RASSF Family.
RASSF6; the Putative Tumor Suppressor of the RASSF Family.
复制标题
rassf6; RASSF家族的推定肿瘤抑制剂。
DOI：
10.3390/cancers7040899
复制
发表时间：
2015-12-09
期刊：
影响因子：
5.2
通讯作者：
Hata Y
中科院分区：
文献类型：
--
作者：
Iwasa H;Jiang X;Hata Y
人类有10个基因属于Ras相关（RA）结构域家族（RASSF）。其中，RASSF 7 ~ RASSF 10在N末端区域具有RA结构域，称为N-RASSF蛋白。RASSF 1至RASSF 6被称为C-RASSF蛋白。C-RASSF蛋白在中间区域具有RA结构域，在C-末端区域具有萨尔瓦多/RASSF/Hippo结构域。RASSF 6还含有PSD-95/Discs large/ZO-1（PDZ）结合基序。RASSF 6的表达在人类癌症中受到表观遗传学抑制，并且通常被认为是肿瘤抑制因子。RASSF 6诱导caspase依赖性和非依赖性细胞凋亡。RASSF 6与哺乳动物Ste 20样激酶（果蝇河马的同源物）相互作用，并与河马途径交叉对话。RASSF 6结合MDM 2并调节p53表达。异源蛋白质-蛋白质相互作用实验也表明了与Ras和凋亡调节因子1（MOAP 1）的相互作用。RASSF 6通过这些蛋白质-蛋白质相互作用调节细胞凋亡和细胞周期，并参与NF-κB和JNK信号通路。我们总结了我们目前对RASSF 6的了解，并讨论了RASSF 6和其他C-RASSF蛋白的共同和不同性质。
Humans have 10 genes that belong to the Ras association (RA) domain family (RASSF). Among them, RASSF7 to RASSF10 have the RA domain in the N-terminal region and are called the N-RASSF proteins. In contradistinction to them, RASSF1 to RASSF6 are referred to as the C-RASSF proteins. The C-RASSF proteins have the RA domain in the middle region and the Salvador/RASSF/Hippo domain in the C-terminal region. RASSF6 additionally harbors the PSD-95/Discs large/ZO-1 (PDZ)-binding motif. Expression of RASSF6 is epigenetically suppressed in human cancers and is generally regarded as a tumor suppressor. RASSF6 induces caspase-dependent and -independent apoptosis. RASSF6 interacts with mammalian Ste20-like kinases (homologs of Drosophila Hippo) and cross-talks with the Hippo pathway. RASSF6 binds MDM2 and regulates p53 expression. The interactions with Ras and Modulator of apoptosis 1 (MOAP1) are also suggested by heterologous protein-protein interaction experiments. RASSF6 regulates apoptosis and cell cycle through these protein-protein interactions, and is implicated in the NF-κB and JNK signaling pathways. We summarize our current knowledge about RASSF6 and discuss what common and different properties RASSF6 and the other C-RASSF proteins have.