Profiles of black and Latin-American patients having pernicious anemia. HLA antigens, lymphocytotoxic antibody, anti-parietal cell antibody serum gastrin levels, and ABO blood groups.
Profiles of black and Latin-American patients having pernicious anemia. HLA antigens, lymphocytotoxic antibody, anti-parietal cell antibody serum gastrin levels, and ABO blood groups.
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患有恶性贫血的黑人和拉丁美洲患者的概况。
DOI：
10.1093/ajcp/75.3.291
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发表时间：
1981
影响因子：
3.5
通讯作者：
Terasaki,PI
中科院分区：
文献类型：
--
作者：
Carmel,R;Ozturk,G;Johnson,CS;Tung,KS;Terasaki,PI
由于恶性贫血在许多黑人妇女中的不寻常表现，对这种疾病在不同种族群体中的进一步表征进行了研究。结果发现：（1）50岁以下的黑人妇女抗壁细胞抗体的流行率明显低于"欧洲"和拉丁美洲患者，甚至是年龄较大的黑人妇女。在这方面，年轻黑人妇女的这种疾病类似于青少年恶性贫血。总体而言，黑人的抗壁细胞抗体患病率低于"欧洲人"和拉丁美洲人，尽管这种差异在统计学上并不显著。一个特别引人注目的发现是，在黑人患者中，抗壁细胞抗体发生的频率远低于抗内因子抗体。(2)对所有已发表的欧洲血统患者的HLA数据的分析表明，恶性贫血与HLA B7的关联较弱。然而，在研究的黑人和拉丁美洲患者中没有发现抗原相关性。HLA-DR分型也没有显示出相关性，这在以前甚至在白人中也没有报道。(3)淋巴细胞毒性抗体在所有种族组中的频率同样增加。(4)血清胃泌素水平并不遵循种族模式;然而，恶性贫血的女性比男性有更高的水平。(5)恶性贫血与A血型无关。
Because of the unusual presentation of pernicious anemia in many black women, a further characterization of this disease among the different racial groups was undertaken. The following were found. (1) Black women under the age of 50 years had a significantly lower prevalence of anti-parietal cell antibody than did “European” and Latin-American patients or even older black women. The disease in the younger black women resembles juvenile pernicious anemia in this respect. Blacks in general had a lower prevalence of anti-parietal cell antibody than did “Europeans” and Latin Americans, though the difference was not statistically significant. A particularly striking finding was that anti-parietal cell antibody occurred much less often than antiintrinsic factor antibody among black patients. (2) An analysis of all published HLA data for patients of European origin indicated a weak association of pernicious anemia with HLAB7. However, no antigen association among the black and Latin-American patients studied was found. HLA-DR typing, not previously reported even for whites, also showed no association. (3) Lymphocytotoxic antibody was equally increased in frequency in all racial groups. (4) Serum gastrin levels did not follow a racial pattern; however, women with pernicious anemia had much higher levels than did men. (5) Pernicious anemia was not associated with blood group A.