METABOLIC-CLEARANCE RATE AND INTERCONVERSION OF ANDROGENS AND THE INFLUENCE OF THE FREE ANDROGEN FRACTION
METABOLIC-CLEARANCE RATE AND INTERCONVERSION OF ANDROGENS AND THE INFLUENCE OF THE FREE ANDROGEN FRACTION
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DOI：
10.1210/jcem-48-2-320
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发表时间：
1979-01-01
影响因子：
5.8
通讯作者：
ANDO, S
中科院分区：
文献类型：
--
作者：
VERMEULEN, A;ANDO, S
应用持续输注技术测定了12名正常男性睾酮（T）向雄烯二酮（A）和双氢睾酮（DHT）的转化率（CR）及A向T和DHT的转化率年龄31-72岁，正常绝经妇女10例，特发性多毛症闭经妇女4例;在另外4只雄性动物中，在输注冷T期间进行这些研究，以将血浆T升高至超生理水平。除了T和DHT的MCR外，A中T和DHT中T的血液转换率（CRBB）也与游离或非睾酮-雌二醇结合球蛋白结合T分数显著相关，但与总血浆T无关。在绝经后妇女，血浆A是迄今为止最重要的前体血浆DHT。The .**图形 **。明显高于 **。图形 **。显然，总血浆A，但只有非特异性结合的T，自由地进入这些转换发生的细胞，血浆A可能是雄激素的一个重要参数。血浆中不到50%的DHT可由A或T的外周转化来解释。而在男性，这可能是由直接的DHT分泌，在（绝经后）妇女的其他前体转化为血浆DHT应予以考虑。
Using the continuous infusion technique, the conversion ratios (CR) of testosterone (T) to androstenedione (A) and dihydrotestosterone (DHT) and of A to T and DHT were determined in 12 normal males (aged 31-72 yr), 10 normal postmenopausal women, and 4 amenorrheic women with idiopathic hirsutism; in 4 additional males these studies were performed during infusion of cold T to increase plasma T to supraphysiological levels. Besides the MCR of T and DHT, the blood conversion ratios (CRBB) of T in A and to a lesser extent of T in DHT were also significantly correlated with the free or the nontestosterone-estradiol-binding globulin-bound T fraction but not with total plasma T. In postmenopausal women, plasma A was by far the most important precursor of plasma DHT. The .**GRAPHIC**. was significantly higher than .**GRAPHIC**. Apparently total plasma A, but only nonspecifically bound T, freely gains access into the cells where these conversions occur and plasma A might be an important parameter of androgenicity. Less than 50% of plasma DHT could be accounted for by peripheral conversion of A or T. Whereas in males this may be explained by direct DHT secretion, in (postmenopausal) women conversion of other precursors to plasma DHT should be considered.