Evasion, suppression and tolerance of Drosophila innate immunity by a male-killing Spiroplasma endosymbiont
Evasion, suppression and tolerance of Drosophila innate immunity by a male-killing Spiroplasma endosymbiont
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DOI：
10.1111/j.1365-2583.2010.01008.x
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发表时间：
2010-08-01
影响因子：
2.6
通讯作者：
Fukatsu, T.
中科院分区：
文献类型：
--
作者：
Anbutsu, H.;Fukatsu, T.
内共生细菌如何应对宿主昆虫的免疫尚不清楚。在这里，我们报告了以前未知的免疫介导的雄性杀伤/非雄性杀伤螺旋体与果蝇宿主之间的相互作用。杀雄螺原体倾向于降低某些抗菌肽基因的组成表达水平，而非杀雄螺原体则没有。在先天免疫组成性上调的突变蝇中，雄性杀灭螺原体的感染密度明显受到抑制，但在成年蝇衰老过程中感染密度却有所增加，这表明雄性杀灭螺原体对免疫攻击具有抵抗力。这些发现表明，昆虫-微生物共生关系的建立和维持不仅涉及免疫逃避，还涉及免疫抑制和耐受。
How endosymbiotic bacteria cope with host insect immunity is poorly understood. Here we report previously unknown aspects of immunity-mediated interactions between male-killing/non-male-killing spiroplasmas and Drosophila host. The male-killing spiroplasma tended to reduce constitutive expression levels of some antimicrobial peptide genes, while the non-male-killing spiroplasma did not. In mutant flies whose innate immunity is constitutively up-regulated, infection densities of the male-killing spiroplasma were significantly suppressed but managed to increase during the aging of adult flies, indicating that the male-killing spiroplasma is resistant to mounted immune attacks. These findings suggest that not only immune evasion but also immune suppression and tolerance are involved in the establishment and maintenance of the insect-microbe symbiotic association.